Fan Haonan, Qiao Zhi, Li Jitian, Shang Guowei, Shang Chunfeng, Chen Songfeng, Leng Zikuan, Su Huifang, Kou Hongwei, Liu Hongjian
Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital)/Henan Institute of Orthopedic and Traumatology, Luoyang 471000, China.
Heliyon. 2024 Feb 8;10(4):e25538. doi: 10.1016/j.heliyon.2024.e25538. eCollection 2024 Feb 29.
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age. The senescence-associated secretory phenotype (SASP), an essential cellular senescence hallmark, is an important mechanism connecting cellular senescence to osteoporosis. This review describes in detail the characteristics of SASPs and their regulatory agencies, and shed fresh light on how SASPs from different senescent cells contribute to osteoporosis development. Furthermore, we summarized various innovative therapy techniques that target SASPs to lower the burden of osteoporosis in the elderly and discussed the potential challenges of SASPs-based therapy for osteoporosis as a new clinical trial.
全球老年人口正在增加，而衰老 是骨质疏松症的一个主要风险因素。随着我们年龄的增长，衰老细胞的积累会对身体产生有害影响。衰老相关分泌表型（SASP）是细胞衰老的一个重要标志，是将细胞衰老与骨质疏松症联系起来的重要机制。本文详细描述了SASP的特征及其调控机制，并对来自不同衰老细胞的SASP如何促进骨质疏松症的发展有了新的认识。此外，我们总结了各种针对SASP的创新治疗技术，以减轻老年人骨质疏松症的负担，并讨论了作为一项新的临床试验，基于SASP的骨质疏松症治疗的潜在挑战。
