Gibson Dennis, Watters Ashlie, Dee Elizabeth, Mehler Philip S
ACUTE Center for Eating Disorders at Denver Health, Denver, Colorado, USA.
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Int J Eat Disord. 2022 Dec;55(12):1853-1858. doi: 10.1002/eat.23839. Epub 2022 Oct 26.
To better understand gastric dimensions in patients diagnosed with restrictive eating disorders (EDs).
In this retrospective study, 56 patients, with restrictive EDs, and 60 gender/age/race-matched patients from an outpatient clinic, were studied. Difference in stomach size, between cohorts, was ascertained, and regression analyses were used to examine associations with stomach size in the ED cohort.
Patients with EDs were found to have significantly enlarged gastric dimensions when compared to the control group (M:14.8 cm [SD: 3.2] vs. 11.4 cm [SD: 2.9], p < .0001). Among the ED cohort, blood urea nitrogen (BUN), on the day of imaging, positively correlated with gastric dimensions (r = .43, p = .0009), while hypoalbuminemia negatively correlated with gastric dimensions (r = -.37, p = .005). BUN and albumin nadir were also significantly associated with stomach size (r = .26, F[2,53] = 9.46, p = .0003). There was no significant correlation between gastric dimensions and ED diagnosis, percent ideal body weight, gender, duration of illness, engagement in vomiting behaviors, diagnosis of superior mesenteric artery syndrome, or use of promotility agents.
Findings in this study suggest that malnutrition, secondary to EDs, may be associated with an enlarged stomach. The relationship between the gastric dimensions and reported GI symptoms in this population remain to be determined.
There are many physiologic changes to the gastrointestinal system that develop with malnutrition but the contribution of these physiologic changes toward the reported GI symptoms and refeeding difficulties is unclear. This is the first study to suggest that patients with malnutrition, secondary to EDs, may be associated with an enlarged stomach, and this potential relationship requires further investigation.
更好地了解诊断为限制性进食障碍（EDs）患者的胃尺寸。
在这项回顾性研究中，对56例患有限制性EDs的患者以及60例来自门诊的性别/年龄/种族匹配的患者进行了研究。确定了两组之间胃大小的差异，并使用回归分析来检查ED队列中与胃大小的关联。
发现与对照组相比，EDs患者的胃尺寸明显增大（男性：14.8厘米[标准差：3.2]对11.4厘米[标准差：2.9]，p <.0001）。在ED队列中，成像当天的血尿素氮（BUN）与胃尺寸呈正相关（r =.43，p =.0009），而低白蛋白血症与胃尺寸呈负相关（r = -.37，p =.005）。BUN和白蛋白最低点也与胃大小显著相关（r =.26，F[2,53] = 9.46，p =.0003）。胃尺寸与ED诊断、理想体重百分比、性别、病程、呕吐行为、肠系膜上动脉综合征诊断或促动力药物使用之间无显著相关性。
本研究结果表明，继发于EDs的营养不良可能与胃扩大有关。该人群中胃尺寸与报告的胃肠道症状之间的关系仍有待确定。
营养不良会导致胃肠道系统发生许多生理变化，但这些生理变化对报告的胃肠道症状和再喂养困难的影响尚不清楚。这是第一项表明继发于EDs的营养不良患者可能与胃扩大有关的研究，这种潜在关系需要进一步研究。
