Babaeenezhad Esmaeel, Naghibalhossaini Fakhraddin, Rajabibazl Masoumeh, Jangravi Zohreh, Hadipour Moradi Forouzan, Fattahi Mohammad Davood, Hoheisel Jörg D, Sarabi Mostafa Moradi, Shahryarhesami Soroosh
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran.
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad 6813816314, Iran.
Noncoding RNA. 2022 Oct 8;8(5):67. doi: 10.3390/ncrna8050067.
Digestive tract cancers represent a serious public health issue. In recent years, evidence has accumulated that microRNA miR-185 is implicated in the pathogenesis of this group of highly malignant tumors. Its expression variations correlate with clinical features, such as tumor size, lymph node metastasis, tumor node metastatic stage, survival, recurrence and response to adjuvant therapy, and have diagnostic and prognostic potential. In this review, we compile, evaluate and discuss the current knowledge about the roles of miR-185 in digestive tract cancers. Interestingly, miR-185 is apparently involved in regulating both tumor suppressive and oncogenic processes. We look at downstream effects as well as upstream regulation. In addition, we discuss the utility of miR-185 for diagnosis and its potential concerning novel therapeutic approaches.
消化道癌症是一个严重的公共卫生问题。近年来，越来越多的证据表明，微小RNA miR-185与这类高恶性肿瘤的发病机制有关。其表达变化与肿瘤大小、淋巴结转移、肿瘤淋巴结转移分期、生存率、复发率及辅助治疗反应等临床特征相关，具有诊断和预后潜力。在本综述中，我们汇总、评估并讨论了目前关于miR-185在消化道癌症中作用的相关知识。有趣的是，miR-185显然参与了肿瘤抑制和致癌过程的调节。我们研究了其下游效应以及上游调控。此外，我们还讨论了miR-185在诊断方面的应用及其在新型治疗方法中的潜力。
