Department of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Wanju 54875, Korea.
Toxins (Basel). 2022 Sep 23;14(10):663. doi: 10.3390/toxins14100663.
() bacteria cause almost all primary skin infections in humans. Bee venom (BV) and melittin (Mel) have multiple effects, including antibacterial and anti-inflammatory activities. This study aims to demonstrate their effects on bacterial mouse skin infection using . The dorsal skin was tape-stripped, then was topically applied. BV or Mel were topically applied to the lesion. The tissues were stained with hematoxylin and eosin, while immunohistochemical staining was performed with anti-neutrophil. -infected skin revealed increased epidermal and dermal layers, but it was reduced in the BV and Mel groups. Finding increased neutrophils in the mice infected with , but the BV and Mel mice showed decreased expression. These results suggest that BV and Mel treatments could reduce the inflammatory reactions and help improve lesions induced by skin infection. This study provides additional assessment of the potential therapeutic effects of BV and Mel in managing skin infection caused by , further suggesting that it could be a candidate for developing novel treatment alternative for streptococcal skin infections.
（）细菌几乎引起人类所有原发性皮肤感染。蜂毒（BV）和蜂肽（Mel）具有多种作用，包括抗菌和抗炎活性。本研究旨在使用 来证明它们对细菌小鼠皮肤感染的作用。用胶带剥离背部皮肤，然后局部应用 。将 BV 或 Mel 局部应用于病变部位。用苏木精和伊红染色组织，同时用抗中性粒细胞进行免疫组织化学染色。感染皮肤的表皮和真皮层增加，但在 BV 和 Mel 组中减少。在感染 的小鼠中发现中性粒细胞增加，但 BV 和 Mel 小鼠的表达减少。这些结果表明，BV 和 Mel 治疗可减轻炎症反应，有助于改善 皮肤感染引起的病变。本研究为评估 BV 和 Mel 在治疗 引起的皮肤感染方面的潜在治疗效果提供了额外依据，进一步表明它可能是开发链球菌皮肤感染新型治疗替代药物的候选药物。
