Paolini Andrea, Vignoli Massimo, Guerri Giulia, Falerno Ilaria, Tamburro Roberto, Simeoni Francesco, Signore Francesca Del, De Bonis Andrea, Collivignarelli Francesco, Salvo Maria Cristina, Cerasoli Ilaria
Faculty of Veterinary Medicine, University of Teramo, Località Piano D'Accio, 64100 Teramo, Italy.
Clinica Veterinaria Borghesiana, 00132 Rome, Italy.
Vet Sci. 2022 Sep 23;9(10):520. doi: 10.3390/vetsci9100520.
The aim of this clinical trial was to evaluate the impacts of administration via the intrarectal route (IR) in cats on their heart and respiratory rates, blood pressure, body temperature, and sedation quality compared to the intramuscular route (IM). The intramuscular group (IMG) received 0.003 mg kg−1 dexmedetomidine, 2 mg kg−1 ketamine, and 0.2 mg kg−1 midazolam while the intrarectal group (IRG) protocol was 0.003 mg kg−1 dexmedetomidine, 4 mg kg−1 ketamine, and 0.4 mg kg−1 midazolam. Cardiorespiratory values, temperature, and sedation score were measured 2 min after administration and then every 5 min up to the 40th minute. Cats belonging to IRG reacted less strongly to the drug, as opposed to those receiving intramuscular administration (2/10 in IRG vs. 8/10 in IMG). Average time between drug administration and standing position was 44.9 ± 5.79 in IRG and 57 ± 9.88 min in IMG. In IRG, maintenance of SpO₂ values is >95% at each time point. Median and range peak of sedation {7 (5)} in IMG occurs at 20th, 25th, and 30th minutes post drug administration while was lower in IRG. Cardiorespiratory values were slightly lower in IMG than in IRG, but always constant in both treatments. Temperature did not differ between groups. At this dosage, although sedation score was higher in IMG, intrarectal route could be efficacious for performing minimally invasive clinical and diagnostic procedures in cats.
本临床试验的目的是评估经直肠给药途径（IR）对猫的心率、呼吸频率、血压、体温和镇静质量的影响，并与肌肉注射途径（IM）进行比较。肌肉注射组（IMG）接受0.003mg/kg右美托咪定、2mg/kg氯胺酮和0.2mg/kg咪达唑仑，而经直肠给药组（IRG）的方案为0.003mg/kg右美托咪定、4mg/kg氯胺酮和0.4mg/kg咪达唑仑。给药后2分钟测量心肺值、体温和镇静评分，然后每5分钟测量一次，直至第40分钟。与接受肌肉注射的猫相比，IRG组的猫对药物的反应较弱（IRG组为2/10，IMG组为8/10）。IRG组给药至站立的平均时间为44.9±5.79分钟，IMG组为57±9.88分钟。在IRG组中，每个时间点的SpO₂值均维持在>95%。IMG组镇静峰值的中位数和范围{7（5）}出现在给药后第20、25和30分钟，而IRG组较低。IMG组的心肺值略低于IRG组，但两种治疗方法中的心肺值均保持恒定。两组之间的体温没有差异。在此剂量下，尽管IMG组的镇静评分较高，但经直肠给药途径对于在猫身上进行微创临床和诊断程序可能是有效的。
