Center for Animal Resources and Collaborative Study, National Institutes of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.
National Institute for Physiological Sciences, National Institutes of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.
Exp Anim. 2023 May 17;72(2):193-198. doi: 10.1538/expanim.22-0110. Epub 2022 Oct 27.
To understand effects of aging and reproductive history in the bones of common marmosets (Callithrix jacchus), mandibles from 79 males and 66 females were analyzed. Dry bone specimen was prepared from dissected mandible, and analyzed using a dual-energy x-ray absorptiometry (DXA) measurement system in terms of bone weight (BnW), bone area (AREA), bone mineral content (BMC), bone mineral density (BMD, ratio of BMC to AREA) and bone mineral ratio (BMR, ratio of BMC to BnW). The mandible bones became porous and thicker with age. The age-related changes in BnW, AREA and BMC showed inflection points at around 1.5-2 Y and 13-15 Y. The period before 1.5-2 Y corresponds to the growth phase, the period between the inflection points is the aging phase, followed by senescence after the second inflection point. BMD increased until 1.5-2 Y and gradually decreased thereafter in males, with a more dramatic decrease in females, probably because of pregnancy and lactation. BMR was stable after reaching its peak by 1 Y, unlike the other parameters we analyzed. BMD of parous female tended to be lower than that of nulliparous female aged 2-5 Y. This study identified some of the particular effects of aging and reproductive history on characteristics of mandible bones in common marmoset.
为了了解衰老和生殖史对普通狨猴（Callithrix jacchus）骨骼的影响，分析了 79 只雄性和 66 只雌性的下颌骨。从解剖的下颌骨中制备干骨标本，并使用双能 X 射线吸收仪（DXA）测量系统分析骨重（BnW）、骨面积（AREA）、骨矿物质含量（BMC）、骨矿物质密度（BMD，BMC 与 AREA 的比值）和骨矿物质比（BMR，BMC 与 BnW 的比值）。随着年龄的增长，下颌骨变得多孔且增厚。BnW、AREA 和 BMC 的年龄相关性变化在 1.5-2 岁和 13-15 岁左右出现拐点。1.5-2 岁之前的时期对应于生长阶段，拐点之间的时期是衰老阶段，第二个拐点之后是衰老阶段。男性的 BMD 直到 1.5-2 岁增加，此后逐渐减少，而女性的减少更为明显，这可能是因为怀孕和哺乳。BMR 在 1 岁达到峰值后保持稳定，与我们分析的其他参数不同。2-5 岁的经产雌性的 BMD 往往低于未产雌性。本研究确定了衰老和生殖史对普通狨猴下颌骨特征的一些特殊影响。
