使用光学相干断层扫描不同显示模式测量近视患者的黄斑视网膜厚度：一项回顾性横断面研究。
Measurement of Foveal Retinal Thickness in Myopic Patients Using Different Display Modes on Optical Coherence Tomography: A Retrospective, Cross-Sectional Study.
作者信息
Lawali Dan Jouma A Maman, Wu Guanrong, Guo Yunxiang, Lin Zhangjie, Wu Qiaowei, Amza Abdou, Du Zijing, Ren Yun, Fang Ying, Dong Xinran, Hu Yunyan, Niu Yongyi, Zhang Hongyang, Yu Honghua, Yang Xiaohong, Hu Yijun
机构信息
Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences/The Second School of Clinical Medicine, Southern Medical University, No. 106 Zhongshan Er Road, Yuexiu District, Guangzhou, 510080, China.
Aier Institute of Refractive Surgery, Refractive Surgery Center, Guangzhou Aier Eye Hospital, Guangzhou, China.
出版信息
Ophthalmol Ther. 2023 Feb;12(1):167-178. doi: 10.1007/s40123-022-00584-x. Epub 2022 Oct 26.
INTRODUCTION
The aim of this work is to investigate the differences in the measurement of foveal retinal thickness in myopic patients between two display modes (1:1 pixel and 1:1 micron) on optical coherence tomography (OCT).
METHODS
Horizontal OCT line scan through the central fovea was used for manual measurement of foveal retinal thickness under the two display modes, and the values were compared using Wilcoxon signed-rank test. Correlations between the OCT image tilting angle (OCT ITA) and differences in OCT measurement were analyzed by Spearman's test.
RESULTS
127 participants with a median age of 28 years, a median spherical equivalent (SE) of - 8.5 D, and a median axial length (AL) of 27.04 mm. There were significant differences between the two display modes, with a median absolute difference (median relative difference) of 13.33 μm (2.75%) for the central foveal thickness (CFT), 5.33 μm (1.28%) for the Henle fiber and outer nuclear layer thickness (HFL + ONL), 3 μm (6.47%) for the external limiting membrane to ellipsoid zone distance (ELM-EZ), and 4 μm (8.77%) for the ellipsoid zone to retinal pigment epithelium distance (EZ-RPE) (all p < 0.05). The differences in foveal retinal thickness between the two display modes were significantly correlated with the OCT ITA (r = 0.732 for CFT, 0.561 for HFL + ONL, 0.642 for ELM-EZ, and 0.471 for EZ-RPE, all p < 0.05).
CONCLUSIONS
Disparities between the two display modes were found in the manual measurement of foveal retinal thickness and correlated to the OCT ITA.
引言
本研究旨在探讨光学相干断层扫描（OCT）中两种显示模式（1:1像素和1:1微米）下近视患者黄斑区视网膜厚度测量的差异。
方法
通过中央凹的水平OCT线扫描用于在两种显示模式下手动测量黄斑区视网膜厚度，并使用Wilcoxon符号秩检验比较测量值。通过Spearman检验分析OCT图像倾斜角（OCT ITA）与OCT测量差异之间的相关性。
结果
127名参与者，年龄中位数为28岁，等效球镜（SE）中位数为-8.5 D，眼轴长度（AL）中位数为27.04 mm。两种显示模式之间存在显著差异，中央凹厚度（CFT）的中位数绝对差异（中位数相对差异）为13.33μm（2.75%），Henle纤维和外核层厚度（HFL+ONL）为5.33μm（1.28%），外界膜至椭圆体带距离（ELM-EZ）为3μm（6.47%），椭圆体带至视网膜色素上皮距离（EZ-RPE）为4μm（8.77%）（所有p<0.05）。两种显示模式下黄斑区视网膜厚度的差异与OCT ITA显著相关（CFT的r=0.732，HFL+ONL的r=0.561，ELM-EZ的r=0.642，EZ-RPE的r=0.471，所有p<0.05）。
结论
在黄斑区视网膜厚度的手动测量中发现两种显示模式之间存在差异，且与OCT ITA相关。
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