Garay Juan Agustín, Silva Juan Eduardo, Di Genaro María Silvia, Davicino Roberto Carlos
División de Inmunología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Argentina.
Instituto Multidisciplinario de Investigaciones Biológicas (IMIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Luis 5700, Argentina.
Biomedicines. 2022 Oct 14;10(10):2570. doi: 10.3390/biomedicines10102570.
Nitric oxide (NO), a signaling molecule, regulates multiple biological functions, including a variety of physiological and pathological processes. In this regard, NO participates in cutaneous inflammations, modulation of mitochondrial functions, vascular diseases, COVID-19, neurologic diseases, and obesity. It also mediates changes in the skeletal muscle function. Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder characterized by the malfunction of phagocytes caused by mutations in some of the genes encoding subunits of the superoxide-generating phagocyte NADPH (NOX). The literature consulted shows that there is a relationship between the production of NO and the NADPH oxidase system, which regulates the persistence of NO in the medium. Nevertheless, the underlying mechanisms of the effects of NO on CGD remain unknown. In this paper, we briefly review the regulatory role of NO in CGD and its potential underlying mechanisms.
一氧化氮（NO）作为一种信号分子，可调节多种生物学功能，包括各种生理和病理过程。在这方面，NO参与皮肤炎症、线粒体功能调节、血管疾病、新冠肺炎、神经疾病和肥胖症。它还介导骨骼肌功能的变化。慢性肉芽肿病（CGD）是一种原发性免疫缺陷疾病，其特征是由编码产生超氧化物的吞噬细胞NADPH（NOX）亚基的某些基因突变导致吞噬细胞功能异常。查阅的文献表明，NO的产生与NADPH氧化酶系统之间存在关联，该系统调节NO在介质中的持久性。然而，NO对CGD影响的潜在机制仍不清楚。在本文中，我们简要综述了NO在CGD中的调节作用及其潜在的机制。
