In our preliminary study, a hot water extract from the fruits of (mulberry) inhibited the secretion of metalloproteinase-1 (MMP-1) against tumor necrosis factor-α (TNF-α)-stimulated human dermal fibroblasts (HDFs), and therefore we researched its active compounds. In the present study, a new phenolic glycoside (oddioside A, ) and 21 known compounds (-) were isolated from the hot water extract from the fruits of by repeated chromatography. The chemical structure of the new compound was elucidated by its spectroscopic data (1D- and 2D-NMR and HRMS) measurement and by acidic hydrolysis. The presence of sargentodoside E (), eugenyl glucoside (), 2--β-d-glucopyranosyl-4,6-dihydroxybenzaldehyde ), 7,8-erythro-7,9,9'-trihydroxy-3,3'-dimethoxy-8--4'-neolignan-4--β-d-glucopyranoside (), pinoresinol-4--β-d-glucopyranoside (), taxifolin-7--β-d-glucopyranoside (), and pinellic acid () were reported from for the first time in this study. The new compound oddioside A () suppressed the secretion of MMP-1 and increased collagen in TNF-α-stimulated HDFs. In addition, the phosphorylation of mitogen-activated protein kinases (MAPKs) was inhibited by oddioside A. In conclusion, the extract from fruits of and its constituent oddioside A may be a potential agent to prevent inflammation-related skin aging and other skin disorders.