Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences & Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
Cancer Center Amsterdam Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Curr Oncol. 2022 Sep 28;29(10):7109-7121. doi: 10.3390/curroncol29100559.
Psychoneurological symptoms are commonly reported by newly diagnosed head and neck cancer (HNC) patients, yet there is limited research on the associations of these symptoms with biomarkers of stress and inflammation. In this article, pre-treatment data of a multi-center cohort of HNC patients were analyzed using a network analysis to examine connections between symptoms (poor sleep quality, anxiety, depression, fatigue, and oral pain), biomarkers of stress (diurnal cortisol slope), inflammation markers (c-reactive protein [CRP], interleukin [IL]-6, IL-10, and tumor necrosis factor alpha [TNF-α]), and covariates (age and body mass index [BMI]). Three centrality indices were calculated: degree (number of connections), closeness (proximity of a variable to other variables), and betweenness (based on the number of times a variable is located on the shortest path between any pair of other variables). In a sample of 264 patients, poor sleep quality and fatigue had the highest degree index; fatigue and CRP had the highest closeness index; and IL-6 had the highest betweenness index. The model yielded two clusters: a symptoms-cortisol slope-CRP cluster and a IL-6-IL-10-TNF-α-age-BMI cluster. Both clusters were connected most prominently via IL-6. Our findings provide evidence that poor sleep quality, fatigue, CRP, and IL-6 play an important role in the interconnections between psychoneurological symptoms and biomarkers of stress and inflammation in newly diagnosed HNC patients.
精神神经症状在新诊断的头颈部癌症（HNC）患者中经常被报告，但这些症状与应激和炎症生物标志物的关联研究有限。在本文中，使用网络分析对头颈部癌症患者多中心队列的预处理数据进行了分析，以检查症状（睡眠质量差、焦虑、抑郁、疲劳和口腔疼痛）、应激生物标志物（日间皮质醇斜率）、炎症标志物（C 反应蛋白 [CRP]、白细胞介素 [IL]-6、IL-10 和肿瘤坏死因子 alpha [TNF-α]）和协变量（年龄和体重指数 [BMI]）之间的联系。计算了三个中心性指数：度（连接数）、接近度（变量与其他变量的接近程度）和介数（基于变量位于其他任何两个变量之间最短路径上的次数）。在 264 名患者的样本中，睡眠质量差和疲劳的度指数最高；疲劳和 CRP 的接近度指数最高；IL-6 的介数指数最高。该模型产生了两个簇：一个是症状-皮质醇斜率-CRP 簇，另一个是 IL-6-IL-10-TNF-α-年龄-BMI 簇。这两个簇通过 IL-6 连接最为紧密。我们的研究结果表明，睡眠质量差、疲劳、CRP 和 IL-6 在新诊断的头颈部癌症患者的精神神经症状与应激和炎症生物标志物之间的相互联系中起着重要作用。
