Department of Chemistry, M.M.D. College, Moradabad, M.J.P. Rohilkhand University, Bareilly 244001, UP, India.
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Biosensors (Basel). 2022 Oct 9;12(10):849. doi: 10.3390/bios12100849.
Serotonin is a very important monoamine neurotransmitter, which takes part in biological and psychological processes. In the present scenario, design and fabrication of a serotonin electrochemical sensor is of great significance. In this study, we have synthesized α-MnO via a hydrothermal synthesis method using potassium permanganate as a precursor. The physiochemical properties, such as structural and phase-purity of the prepared α-MnO, were investigated by various characterization techniques and methods (powder X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy). Furthermore, the serotonin sensor was fabricated using α-MnO as an electrode modifier or electro-catalyst. The bare glassy carbon electrode (GCE) was adopted as a working substrate, and its active carbon surface was modified with the synthesized α-MnO. This modified GCE () was explored as a serotonin sensor. The electrochemical investigations showed that the has excellent electro-catalytic properties towards determination of serotonin. The exhibits an excellent detection limit (DL) of 0.14 µM, along with good sensitivity of 2.41 µAµM cm. The also demonstrated excellent selectivity for determination of serotonin in the presence of various electro-active/interfering molecules. The also exhibits good cyclic repeatability, stability, and storage stability.
血清素是一种非常重要的单胺神经递质，参与生物和心理过程。在当前的情况下，设计和制造血清素电化学传感器具有重要意义。在这项研究中，我们使用高锰酸钾作为前体，通过水热合成方法合成了α-MnO。通过各种表征技术和方法（粉末 X 射线衍射、扫描电子显微镜和能谱）研究了所制备的α-MnO 的物理化学性质，如结构和相纯度。此外，还使用α-MnO 作为电极修饰剂或电催化剂来制备血清素传感器。采用玻碳电极（GCE）作为工作基板，用合成的α-MnO 修饰其活性碳表面。修饰后的 GCE（）被用作血清素传感器。电化学研究表明，对测定血清素有极好的电催化性能。该传感器具有出色的检测限（DL）为 0.14µM，以及良好的灵敏度为 2.41µAµM cm。该传感器还表现出对在存在各种电活性/干扰分子的情况下测定血清素的优异选择性。该传感器还表现出良好的循环重复性、稳定性和储存稳定性。
