Yu Yanxun V, Xue Weikang, Chen Yuanhua
Department of Neurology, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430070, China.
Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430070, China.
Brain Sci. 2022 Oct 9;12(10):1368. doi: 10.3390/brainsci12101368.
Multisensory integration refers to sensory inputs from different sensory modalities being processed simultaneously to produce a unitary output. Surrounded by stimuli from multiple modalities, animals utilize multisensory integration to form a coherent and robust representation of the complex environment. Even though multisensory integration is fundamentally essential for animal life, our understanding of the underlying mechanisms, especially at the molecular, synaptic and circuit levels, remains poorly understood. The study of sensory perception in has begun to fill this gap. We have gained a considerable amount of insight into the general principles of sensory neurobiology owing to ' highly sensitive perceptions, relatively simple nervous system, ample genetic tools and completely mapped neural connectome. Many interesting paradigms of multisensory integration have been characterized in , for which input convergence occurs at the sensory neuron or the interneuron level. In this narrative review, we describe some representative cases of multisensory integration in , summarize the underlying mechanisms and compare them with those in mammalian systems. Despite the differences, we believe is able to provide unique insights into how processing and integrating multisensory inputs can generate flexible and adaptive behaviors. With the emergence of whole brain imaging, the ability of to monitor nearly the entire nervous system may be crucial for understanding the function of the brain as a whole.
多感官整合是指来自不同感觉模态的感觉输入被同时处理以产生一个统一的输出。动物被来自多种模态的刺激所包围，它们利用多感官整合来形成对复杂环境的连贯且稳健的表征。尽管多感官整合对动物生命至关重要，但我们对其潜在机制的理解，尤其是在分子、突触和神经回路层面，仍然知之甚少。对[某种动物]感觉感知的研究已开始填补这一空白。由于[该动物]具有高度敏感的感知、相对简单的神经系统、丰富的遗传工具以及完全绘制的神经连接组，我们对感觉神经生物学的一般原理有了相当多的了解。在[该动物]中已经表征了许多有趣的多感官整合范式，其输入汇聚发生在感觉神经元或中间神经元水平。在这篇综述中，我们描述了[该动物]多感官整合的一些代表性案例，总结了潜在机制，并将它们与哺乳动物系统中的机制进行比较。尽管存在差异，但我们相信[该动物]能够为理解多感官输入的处理和整合如何产生灵活且适应性行为提供独特的见解。随着全脑成像的出现，[该动物]监测几乎整个神经系统的能力对于理解整个大脑的功能可能至关重要。
