Zhang Ziyi, Liu Peng, Kwapong William Robert, Wu Bo, Liu Ming, Zhang Shuting
Department of Neurology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Department of Emergency, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China.
Brain Sci. 2022 Oct 14;12(10):1391. doi: 10.3390/brainsci12101391.
Recent reports suggest that results from imaging retinal microvascular changes with optical coherence tomography angiography (OCTA) in dementia patients reflect cerebral microcirculation changes that occur during dementia. Macula microvascular impairment has been shown in dementia patients compared to controls, but very little is known about its correlation with radiological visual rating scores associated with dementia. We aimed to explore the association between retinal microvasculature and radiological visual rating in early-onset dementia (EOD) patients. Swept-source OCTA (SS-OCTA) was used to image the retinal microvasculature of all EOD patients. Automated software in the OCTA tool segmented and measured the densities in the superficial vascular plexus (SVC) and deep vascular plexus (DVC) and foveal avascular zone (FAZ) areas. Radiological visual rating scores were evaluated on all MR images. Medial temporal lobe atrophy (MTA) scores significantly correlated with FAZ area ( = 0.031) in EOD patients after adjusting for risk factors. PWMH correlated with SVC ( = 0.032) while DWMH significantly correlated with SVC ( = 0.007), DVC ( = 0.018) and FAZ ( = 0.001) in EOD patients. FAZ changes correlated with MTA scores in EOD patients, while retinal microvasculature correlated with white matter hyperintensity. Our report suggests that microvascular changes in the retina may reflect cortical changes in the brain of EOD patients.
最近的报告表明，痴呆症患者通过光学相干断层扫描血管造影（OCTA）对视网膜微血管变化进行成像的结果反映了痴呆症发生期间大脑微循环的变化。与对照组相比，痴呆症患者已出现黄斑微血管损伤，但对于其与痴呆症相关的放射学视觉评分的相关性知之甚少。我们旨在探讨早发性痴呆（EOD）患者视网膜微血管与放射学视觉评分之间的关联。使用扫频源OCTA（SS-OCTA）对所有EOD患者的视网膜微血管进行成像。OCTA工具中的自动化软件对浅表血管丛（SVC）、深部血管丛（DVC）和黄斑无血管区（FAZ）区域的密度进行分割和测量。对所有磁共振图像评估放射学视觉评分。在调整风险因素后，EOD患者的内侧颞叶萎缩（MTA）评分与FAZ面积显著相关（=0.031）。在EOD患者中，脑白质高信号（PWMH）与SVC相关（=0.032），而深部脑白质高信号（DWMH）与SVC（=0.007）、DVC（=0.018）和FAZ（=0.001）显著相关。EOD患者中FAZ变化与MTA评分相关，而视网膜微血管与白质高信号相关。我们的报告表明，视网膜微血管变化可能反映EOD患者大脑中的皮质变化。
