Patriota Pollyanna, Borloz Sylvie, Ruiz Inge, Bouthors Thérèse, Rezzi Serge, Marques-Vidal Pedro, Hauschild Michael
Swiss Nutrition and Health Foundation, 1066 Epalinges, Switzerland.
Paediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Department Women-Mother-Child-CHUV, Children's Hospital-CHUV, Chem. de Montétan 16, 1004 Lausanne, Switzerland.
Children (Basel). 2022 Oct 6;9(10):1527. doi: 10.3390/children9101527.
Background: Hypovitaminosis D is common in populations with obesity. This study aimed at assessing (1) the prevalence of hypovitaminosis D and (2) the associations between vitamin D levels and cardiovascular risk factors in adolescents attending a reference centre for the treatment of obesity. Design: Cross-sectional pilot study conducted in the paediatric obesity unit of the Lausanne university hospital, Switzerland. Methods: Participants were considered eligible if they (1) were aged between 10 to 16.9 years and (2) consulted between 2017 and 2021. Participants were excluded if (1) they lacked vitamin D measurements or (2) the vitamin D measurement was performed one month after the base anthropometric assessment. Hypovitaminosis D was considered if the vitamin D level was <30 ng/mL (<75 nmol/L). Severe obesity was defined as a BMI z-score > 3 SD. Results: We included 52 adolescents (31% girls, mean age 13 ± 2 years, 33% with severe obesity). The prevalence of hypovitaminosis D was 87.5% in girls and 88.9% in boys. The vitamin D levels were inversely associated with BMI, Spearman r and 95% CI: −0.286 (−0.555; −0.017), p = 0.037; they were not associated with the BMI z-score: −0.052 (−0.327; 0.224), p = 0.713. The vitamin D levels were negatively associated with the parathormone levels (−0.353 (−0.667; −0.039), p = 0.028) and positively associated with the calcium levels (0.385 (0.061; 0.708), p = 0.020), while no association was found between vitamin D levels and blood pressure and lipid or glucose levels. Conclusion: almost 9 out of 10 adolescents with obesity in our cohort presented with hypovitaminosis D. Hypovitaminosis D does not seem to be associated with a higher cardiovascular risk profile in this group.
维生素D缺乏症在肥胖人群中很常见。本研究旨在评估（1）维生素D缺乏症的患病率，以及（2）在一家肥胖治疗参考中心就诊的青少年中维生素D水平与心血管危险因素之间的关联。设计：在瑞士洛桑大学医院儿科肥胖科进行的横断面试点研究。方法：符合以下条件的参与者被认为合格：（1）年龄在10至16.9岁之间，（2）在2017年至2021年期间就诊。如果参与者（1）缺乏维生素D测量值，或（2）在基础人体测量评估后一个月进行维生素D测量，则被排除。如果维生素D水平<30 ng/mL（<75 nmol/L），则认为存在维生素D缺乏症。重度肥胖定义为BMI z评分>3个标准差。结果：我们纳入了52名青少年（31%为女孩，平均年龄13±2岁，33%为重度肥胖）。女孩中维生素D缺乏症的患病率为87.5%，男孩中为88.9%。维生素D水平与BMI呈负相关，Spearman相关系数r及95%置信区间：−0.286（−0.555；−0.017），p = 0.037；与BMI z评分无关联：−0.052（−0.327；0.224），p = 0.713。维生素D水平与甲状旁腺激素水平呈负相关（−0.353（−0.667；−0.039），p = 0.028），与钙水平呈正相关（0.385（0.061；0.708），p = 0.020），而维生素D水平与血压、血脂或血糖水平之间未发现关联。结论：在我们的队列中，近十分之九的肥胖青少年存在维生素D缺乏症。在该组中，维生素D缺乏症似乎与更高的心血管风险特征无关。
