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乳腺胶原蛋白组织：因患者年龄和乳腺象限而异

Breast Collagen Organization: Variance by Patient Age and Breast Quadrant.

作者信息

Asiimwe Arnold Caleb, Marin Monica Pernia, Salvatore Mary

机构信息

Department of Radiology, Columbia University Irving Medical Center, 177 Fort Washington Avenue, New York, NY 10032, USA.

出版信息

Diagnostics (Basel). 2024 Aug 12;14(16):1748. doi: 10.3390/diagnostics14161748.

DOI:10.3390/diagnostics14161748
PMID:39202236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353690/
Abstract

Breast density is an important marker for increased breast cancer risk, but the ideal marker would be more specific. Breast compactness, which reflects the focal density of collagen fibers, parallels breast cancer occurrence being highest in the upper outer quadrants of the breast. In addition, it peaks during the same time frame as breast cancer in women. Improved biomarkers for breast cancer risk could pave the way for patient-specific preventive strategies.

摘要

乳腺密度是乳腺癌风险增加的一个重要指标，但理想的指标应更具特异性。乳腺致密性反映了胶原纤维的局灶性密度，与乳腺癌的发生情况相似，在乳腺的上外象限最高。此外，它在女性乳腺癌发病的同一时间段达到峰值。改进的乳腺癌风险生物标志物可为针对患者的预防策略铺平道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/fdf34f709483/diagnostics-14-01748-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/878bdb5efe0a/diagnostics-14-01748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/4b03a99b2577/diagnostics-14-01748-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/63792b18d5fc/diagnostics-14-01748-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/fdf34f709483/diagnostics-14-01748-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/878bdb5efe0a/diagnostics-14-01748-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/4b03a99b2577/diagnostics-14-01748-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/63792b18d5fc/diagnostics-14-01748-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9baf/11353690/fdf34f709483/diagnostics-14-01748-g004a.jpg

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本文引用的文献

1
Unveiling Collagen's Role in Breast Cancer: Insights into Expression Patterns, Functions and Clinical Implications.揭示胶原蛋白在乳腺癌中的作用：对表达模式、功能及临床意义的见解
Int J Gen Med. 2024 May 2;17:1773-1787. doi: 10.2147/IJGM.S463649. eCollection 2024.
2
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.机械敏感性激素信号促进乳腺祖细胞扩增和乳腺癌风险。
Cell Stem Cell. 2024 Jan 4;31(1):106-126.e13. doi: 10.1016/j.stem.2023.12.002.
3
Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis.
乳房硬度，癌症的一个风险因素以及放射学在诊断中的作用。
J Transl Med. 2023 Aug 30;21(1):582. doi: 10.1186/s12967-023-04457-0.
4
Chest CT for Breast Cancer Diagnosis.用于乳腺癌诊断的胸部CT
Life (Basel). 2022 Oct 26;12(11):1699. doi: 10.3390/life12111699.
5
Recent Advances in the Aging Microenvironment of Breast Cancer.乳腺癌衰老微环境的最新进展
Cancers (Basel). 2022 Oct 12;14(20):4990. doi: 10.3390/cancers14204990.
6
Lysyl Oxidase Family Enzymes and Their Role in Tumor Progression.赖氨酰氧化酶家族酶及其在肿瘤进展中的作用。
Int J Mol Sci. 2022 Jun 2;23(11):6249. doi: 10.3390/ijms23116249.
7
Correlation between cumulative mammographic density and age-specific incidence of breast cancer: A biethnic study in Israel.累积乳腺密度与乳腺癌特定年龄发病率的相关性：以色列的一项双民族研究。
Int J Cancer. 2022 Jun 15;150(12):1968-1977. doi: 10.1002/ijc.33957. Epub 2022 Mar 9.
8
Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype.衰老乳房细胞外基质促使乳腺上皮细胞向侵袭性和癌样表型转化。
Adv Sci (Weinh). 2021 Nov;8(22):e2100128. doi: 10.1002/advs.202100128. Epub 2021 Oct 7.
9
Aligned forces: Origins and mechanisms of cancer dissemination guided by extracellular matrix architecture.成束排列的力量：由细胞外基质架构指导的癌症扩散的起源和机制。
Curr Opin Cell Biol. 2021 Oct;72:63-71. doi: 10.1016/j.ceb.2021.05.004. Epub 2021 Jun 27.
10
The potential role of dietary plant ingredients against mammary cancer: a comprehensive review.膳食植物成分对乳腺癌的潜在作用：综述
Crit Rev Food Sci Nutr. 2022;62(10):2580-2605. doi: 10.1080/10408398.2020.1855413. Epub 2020 Dec 15.