Kim So Young, Yoo Dae Myoung, Chung Juyong, Choi Hyo Geun
Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14066, Korea.
Diagnostics (Basel). 2022 Sep 23;12(10):2297. doi: 10.3390/diagnostics12102297.
Previous researchers have suggested an elevated risk of thyroid cancer (TC) in patients with psoriasis with mixed results. The current study evaluated the relationship of psoriasis with the risk of TC in an adult population. The data from the Korean National Health Insurance Service—Health Screening Cohort ≥ 40 years old were analyzed. In total, 6822 patients with TC were equalized with 27,288 control participants using overlap weighting adjustment based on the propensity score. The history of psoriasis was compared between the TC and control groups using multivariable logistic regression analysis. Secondary analyses were conducted according to age, sex, income, region of residence, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, obesity, smoking, alcohol consumption, the Charlson Comorbidity Index scores, hypothyroidism, goiter, thyrotoxicosis, and thyroiditis. The history of psoriasis was not different in patients with TC (overlap-weighted odds ratio (OR) = 1.02, 95% confidence intervals (CI) = 0.85−1.22). The <55-year-old group showed a high rate of TC associated with psoriasis (overlap-weighted OR = 1.69, 95% CI = 1.22−2.36, p = 0.002). The population without hypothyroidism demonstrated an increased rate of TC related to psoriasis (overlap-weighted OR = 1.29, 95% CI = 1.06−1.57, p = 0.012). The patients with hypothyroidism showed a low rate of TC for psoriasis (overlap-weighted OR = 0.59, 95% CI = 0.37−0.96, p = 0.034). None of the other subgroups showed an association between psoriasis and TC. Psoriasis was not related to the risk of TC in the overall adult population. Young adults and populations without hypothyroidism indicated an elevated rate of TC for psoriasis.
先前的研究表明，银屑病患者患甲状腺癌（TC）的风险升高，但结果不一。本研究评估了成年人群中银屑病与TC风险之间的关系。分析了韩国国民健康保险服务机构——健康筛查队列中40岁及以上人群的数据。总共6822例TC患者与27288名对照参与者通过基于倾向评分的重叠加权调整进行了均衡。使用多变量逻辑回归分析比较了TC组和对照组之间的银屑病病史。根据年龄、性别、收入、居住地区、收缩压、舒张压、空腹血糖、总胆固醇、肥胖、吸烟、饮酒、查尔森合并症指数评分、甲状腺功能减退、甲状腺肿、甲状腺毒症和甲状腺炎进行了二次分析。TC患者的银屑病病史无差异（重叠加权比值比（OR）=1.02，95%置信区间（CI）=0.85−1.22）。<55岁组显示银屑病相关的TC发生率较高（重叠加权OR=1.69，95%CI=1.22−2.36，p=0.002）。无甲状腺功能减退的人群中，银屑病相关的TC发生率增加（重叠加权OR=1.29，95%CI=1.06−1.57，p=0.012）。甲状腺功能减退患者中，银屑病的TC发生率较低（重叠加权OR=0.59，95%CI=0.37−0.96，p=0.034）。其他亚组均未显示银屑病与TC之间存在关联。在总体成年人群中，银屑病与TC风险无关。年轻人和无甲状腺功能减退的人群中，银屑病的TC发生率较高。
