School of Public Health, Dali University, Dali 671000, China.
Int J Environ Res Public Health. 2022 Oct 18;19(20):13433. doi: 10.3390/ijerph192013433.
For a long time, the epidemic situation of hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus (HV) in Yunnan Province of China has been relatively severe. The molecular epidemiology and host characteristics of HV in Yunnan Province are still not completely clear, and the systematic and long-term investigation of the epidemic area is very limited. In this study, a total of 488 murine-shaped animals were captured in the three regions of Mile City, Mangshi City and Lianghe County in Yunnan Province, and then the type of HV was identified by multiplex real-time RT-PCR and sequenced. The results indicate that 2.46% of the murine-shaped animal specimens were infected with HV. A new subtype of Seoul virus (SEOV) was found in the rare rat species in Lianghe County, and the two strains of this new subtype were named YNLH-K40 and YNLH-K53. Through the phylogenetic analysis of this new subtype, it is shown that this new subtype is very similar to the type S5 of SEOV, which is previously described as the main cause for the high incidence of HFRS in Longquan City, Zhejiang Province, China. This new subtype is highly likely to cause human infection and disease. Therefore, in addition to further promoting the improvement of the HV gene database and strengthening the discovery and monitoring of the host animals in Yunnan Province, more attention should be paid to the pathogenic potential of the newly discovered HV type.
长期以来，中国云南省汉坦病毒（HV）引起的肾综合征出血热（HFRS）疫情一直较为严重。云南省 HV 的分子流行病学和宿主特征尚不完全清楚，对疫区的系统和长期调查非常有限。本研究共在云南省弥勒市、芒市和梁河县三个地区捕获了 488 只鼠形动物，然后通过多重实时 RT-PCR 鉴定 HV 类型并进行测序。结果表明，2.46%的鼠形动物标本感染了 HV。在梁河县的稀有鼠种中发现了一种新的汉城病毒（SEOV）亚型，该新亚型的两个毒株分别命名为 YNLH-K40 和 YNLH-K53。通过对该新亚型的系统进化分析表明，该新亚型与此前描述的导致中国浙江省龙泉市 HFRS 高发的 SEOV 型 S5 非常相似。该新亚型极有可能导致人类感染和发病。因此，除了进一步推动 HV 基因数据库的完善，加强云南省宿主动物的发现和监测外，还应更加关注新发现的 HV 型的致病潜力。
