Kim Byung Sik, Lee Yonggu, Park Jin-Kyu, Lim Young-Hyo, Shin Jeong-Hun
Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri-si 11923, Korea.
Division of Cardiology, Department of Internal Medicine, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul 04763, Korea.
J Pers Med. 2022 Sep 30;12(10):1611. doi: 10.3390/jpm12101611.
The estimated pulse wave velocity (ePWV) can predict adverse cardiovascular disease (CVD) outcomes in patients with increased CVD risks. However, data on its predictive capacity for CVD outcomes in the general population are limited. This study aimed to investigate the association between the ePWV and CVD outcomes among Korean adults. Ten thousand thirty patients aged 40-69 years from the Ansung-Ansan cohort in a prospective community-based cohort study were followed up for over 18 years. The ePWV was categorized into quartiles. Cox proportional hazard models were used to estimate the risk of cardiovascular (CV) mortality and CVD outcomes (composites of CV mortality, myocardial infarction, coronary artery disease, stroke, heart failure, and peripheral artery disease). The incidence of CV mortality and CVD outcomes was 7.0% and 22.1% in the fourth (highest) ePWV quartile and 0.1% and 4.5% in the first (lowest) quartile, respectively. After relevant covariate adjustments, the patients in the fourth quartile showed a significantly higher CV mortality risk (hazard ratio (HR), 7.57; 95% confidence interval (CI), 1.83-31.25). The patients in the third and fourth quartiles had higher CVD outcome risks (third: HR, 1.61; 95% CI, 1.19-2.16; fourth: HR, 1.56; 95% CI, 1.05-2.31) than those in the first quartile. This association was more clearly observed among women than among men. An elevated ePWV is associated with CV mortality and CVD outcomes. The ePWV is expected to serve as a potential marker for identifying high-risk groups for CVD events.
估计脉搏波速度（ePWV）可预测心血管疾病（CVD）风险增加患者的不良心血管疾病结局。然而，关于其在一般人群中对CVD结局的预测能力的数据有限。本研究旨在调查韩国成年人中ePWV与CVD结局之间的关联。在一项基于社区的前瞻性队列研究中，对来自安城 - 安山队列的10030名40 - 69岁患者进行了超过18年的随访。ePWV被分为四分位数。采用Cox比例风险模型估计心血管（CV）死亡率和CVD结局（CV死亡率、心肌梗死、冠状动脉疾病、中风、心力衰竭和外周动脉疾病的综合）的风险。在ePWV第四（最高）四分位数组中，CV死亡率和CVD结局的发生率分别为7.0%和22.1%，而在第一（最低）四分位数组中分别为0.1%和4.5%。经过相关协变量调整后，第四四分位数组的患者显示出显著更高的CV死亡风险（风险比（HR），7.57；95%置信区间（CI），1.83 - 31.25）。第三和第四四分位数组的患者比第一四分位数组的患者具有更高的CVD结局风险（第三组：HR，1.61；95% CI，1.19 - 2.16；第四组：HR，1.56；95% CI，1.05 - 2.31）。这种关联在女性中比在男性中更明显。ePWV升高与CV死亡率和CVD结局相关。ePWV有望作为识别CVD事件高危人群的潜在标志物。
