Leodori Giorgia, Pellicano Chiara, Basile Valerio, Colalillo Amalia, Navarini Luca, Gigante Antonietta, Gulli Francesca, Marino Mariapaola, Basile Umberto, Rosato Edoardo
Department of Translational and Precision Medicine, Sapienza University of Rome, 00189 Rome, Italy.
Clinical Pathology Unit and Cancer Biobank, Department of Research and Advanced Technologies, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
J Pers Med. 2022 Oct 19;12(10):1737. doi: 10.3390/jpm12101737.
The aim was to evaluate the longitudinal association between basal serum adiponectin and repeated measurements of skin thickness during 12 months of follow-up in systemic sclerosis (SSc) patients. We enrolled SSc patients with disease duration > 2 years in a prospective observational study. Skin thickness was measured at baseline and after 12 months of follow-up with modified Rodnan skin score (mRSS). Baseline serum adiponectin was determined using a commercial ELISA kit. We enrolled 66 female SSc patients (median age 54 years, IQR 42−62 years). The median disease duration was 12 (IQR 8−16) years and median baseline serum adiponectin was 9.8 (IQR 5.6−15.6) mcg/mL. The median mRSS was 10 (IQR 6−18) at baseline and 12 (IQR 7−18) at follow-up. A significant correlation was observed between baseline serum adiponectin and disease duration (r = 0.264, p < 0.05), age (r = 0.515, p < 0.0001), baseline mRSS (r = −0.303, p < 0.05), and mRSS at follow-up (r = −0.322, p < 0.001). In multiple regression analysis, only mRSS at follow-up showed an inverse correlation with baseline serum adiponectin (β = −0.132, p < 0.01). The reduction in serum adiponectin levels is correlated with skin thickness.
目的是评估系统性硬化症（SSc）患者在12个月随访期间基础血清脂联素与重复测量皮肤厚度之间的纵向关联。我们纳入病程超过2年的SSc患者进行一项前瞻性观察性研究。在基线和随访12个月后，使用改良Rodnan皮肤评分（mRSS）测量皮肤厚度。使用商用ELISA试剂盒测定基线血清脂联素。我们纳入了66名女性SSc患者（中位年龄54岁，四分位间距42 - 62岁）。中位病程为12（四分位间距8 - 16）年，中位基线血清脂联素为9.8（四分位间距5.6 - 15.6）mcg/mL。基线时mRSS中位数为10（四分位间距6 - 18），随访时为12（四分位间距7 - 18）。观察到基线血清脂联素与病程（r = 0.264，p < 0.05）、年龄（r = 0.515，p < 0.0001）、基线mRSS（r = -0.303，p < 0.05）和随访时mRSS（r = -0.322，p < 0.001）之间存在显著相关性。在多元回归分析中，仅随访时的mRSS与基线血清脂联素呈负相关（β = -0.132，p < 0.01）。血清脂联素水平的降低与皮肤厚度相关。
