Department of Dermatology, The University of Tokyo Graduate School of Medicine, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 1138655, Japan.
Department of Biostatistics, School of Public Health, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Arthritis Res Ther. 2019 May 28;21(1):129. doi: 10.1186/s13075-019-1919-6.
Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc). Here, we firstly investigated the correlation between skin thickness score and quantitative measurements of each organ involvement in Japanese patients with SSc.
All Japanese SSc patients hospitalized to our clinic for initial evaluation of SSc were selected. Skin thickness was evaluated by modified Rodnan total skin thickness score (mRSS). Relationship between mRSS and prevalence or incidence of organ involvements was examined by logistic analyses. Correlation between mRSS and quantitative measurements of organ involvements was examined by correlation analyses and regression analyses.
We recruited 198 patients into our study. The mean disease duration was 7.3 years with the mean follow-up duration of 3.2 years. Multivariate logistic regression analyses revealed that higher mRSS is related to higher prevalence of interstitial lung disease (P < 0.05), restrictive impairment (P < 0.01), and diffusion impairment (P < 0.05) of the lung. Correlation analyses revealed mRSS negatively correlates with forced vital capacity (P < 0.001) and diffusing capacity (P < 0.001) of the lung. Correlation between longitudinal change of mRSS and that of forced vital capacity (P < 0.05) or diffusing capacity (P < 0.001) of the lung was also demonstrated.
Skin thickness score significantly correlates with quantitative measurements of lung involvement in Japanese patients with SSc.
先前的研究表明，皮肤厚度评分与系统性硬化症（SSc）器官受累的存在之间存在关系。在这里，我们首次研究了皮肤厚度评分与日本 SSc 患者每种器官受累的定量测量之间的相关性。
选择所有因 SSc 初次评估而住院到我院的日本 SSc 患者。采用改良的 Rodnan 总皮肤厚度评分（mRSS）评估皮肤厚度。通过逻辑回归分析检查 mRSS 与器官受累的患病率或发病率之间的关系。通过相关分析和回归分析检查 mRSS 与器官受累的定量测量之间的相关性。
我们共招募了 198 名患者参加本研究。平均疾病持续时间为 7.3 年，平均随访时间为 3.2 年。多变量逻辑回归分析显示，较高的 mRSS 与间质性肺病（ILD）的高患病率（P<0.05）、限制性损害（P<0.01）和肺弥散功能障碍（P<0.05）有关。相关分析显示 mRSS 与肺的用力肺活量（P<0.001）和弥散量（P<0.001）呈负相关。还证明了 mRSS 的纵向变化与用力肺活量（P<0.05）或弥散量（P<0.001）的纵向变化之间的相关性。
皮肤厚度评分与日本 SSc 患者肺受累的定量测量显著相关。
