二价铁和三价铁对大鼠肠道铝吸收的影响。

The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats.

作者信息

Van der Voet G B, De Wolff F A

出版信息

Toxicol Appl Pharmacol. 1987 Sep 15;90(2):190-7. doi: 10.1016/0041-008x(87)90326-7.

Abstract

The effect of iron (Fe) on the intestinal absorption of aluminum (A1) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The gut was perfused with media containing 0.0, 10.0, 15.0, 20.0, and 25.0 mmol/liter Al chloride and 5 mmol/liter Fe(II) or Fe(III) chloride at pH 3.0. Neither luminal disappearance nor intestinal absorption of A1 were affected by Fe(III). Fe(II), however, enhanced luminal disappearance and reduced absorption of Al.

摘要

采用大鼠小肠原位灌注系统并结合体循环和门静脉采血，研究了铁（Fe）对铝（Al）肠道吸收的影响。在pH值为3.0的条件下，用含有0.0、10.0、15.0、20.0和25.0 mmol/升氯化铝以及5 mmol/升氯化亚铁（Fe(II)）或氯化铁（Fe(III)）的培养基灌注肠道。Fe(III)对铝的肠腔消失和肠道吸收均无影响。然而，Fe(II)增强了铝的肠腔消失并减少了其吸收。