大鼠肠道对铝的吸收：肠腔内pH值和铝浓度的影响。

Intestinal absorption of aluminum in rats: effect of intraluminal pH and aluminum concentration.

作者信息

van der Voet G B, de Wolff F A

出版信息

J Appl Toxicol. 1986 Feb;6(1):37-41. doi: 10.1002/jat.2550060108.

Abstract

The intestinal absorption of aluminum (Al) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The jejunum-ileum was perfused with media containing 4.63, 9.25 and 18.50 mmol l-1 Al chloride at pH 4.0 and 7.0. Both mucosal retention was not affected by pH but at lower pH more Al was released into the blood. The amount of Al which appeared in the blood was linearly related to the mucosal retention. The Al release into the blood was much less (mumol l-1) than the mucosal retention (mmol l-1). It is concluded that the intestinal absorption of Al is pH- and concentration-dependent.

摘要

采用大鼠小肠原位灌注系统并结合体循环和门静脉采血，研究了铝（Al）的肠道吸收情况。在pH值为4.0和7.0的条件下，用含有4.63、9.25和18.50 mmol l-1氯化铝的培养基灌注空肠-回肠。黏膜铝潴留不受pH值影响，但在较低pH值时，更多的铝释放到血液中。血液中出现的铝量与黏膜铝潴留呈线性关系。铝释放到血液中的量（μmol l-1）远低于黏膜铝潴留量（mmol l-1）。研究得出结论，铝的肠道吸收取决于pH值和浓度。