Tucker Matthew S, Khan Asis, Jenkins Mark C, Dubey Jitender P, Rosenthal Benjamin M
Animal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USA.
Microorganisms. 2022 Oct 6;10(10):1977. doi: 10.3390/microorganisms10101977.
is an enigmatic human parasite that sickens thousands of people worldwide. The scarcity of research material and lack of any animal model or cell culture system slows research, denying the produce industry, epidemiologists, and regulatory agencies of tools that might aid diagnosis, risk assessment, and risk abatement. Fortunately, related species offer a strong foundation when used as surrogates to study parasites of this type. Species of lend themselves especially well as surrogates for Those that infect poultry can be produced in abundance, share many biological features with , pose no risk to the health of researchers, and can be studied in their natural hosts. Here, we overview the actual and potential uses of such surrogates to advance understanding of biology, diagnostics, control, and genomics, focusing on opportunities to improve prevention, surveillance, risk assessment, and risk reduction. Studying surrogates accelerates progress, closing important research gaps and refining promising tools for producers and food safety regulators to monitor and ameliorate the food safety risks imposed by this emerging, enigmatic parasite.
是一种神秘的人体寄生虫,在全球范围内使数千人患病。研究材料的稀缺以及缺乏任何动物模型或细胞培养系统减缓了研究进程,使农产品行业、流行病学家和监管机构无法获得可能有助于诊断、风险评估和风险消除的工具。幸运的是,相关物种在用作研究此类寄生虫的替代物时提供了坚实的基础。物种特别适合作为的替代物。那些感染家禽的物种可以大量生产,与具有许多生物学特征,对研究人员的健康没有风险,并且可以在其自然宿主中进行研究。在这里,我们概述了此类替代物在推进对生物学、诊断、控制和基因组学的理解方面的实际和潜在用途,重点关注改善预防、监测、风险评估和风险降低的机会。研究替代物加速了进展,填补了重要的研究空白,并为生产者和食品安全监管机构完善了有前景的工具,以监测和减轻这种新出现的神秘寄生虫带来的食品安全风险。