Lyu Juanjuan, Kou Fangfang, Men Xiangyu, Liu Yinhui, Tang Li, Wen Shu
Department of Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Microorganisms. 2022 Oct 19;10(10):2066. doi: 10.3390/microorganisms10102066.
Allergic respiratory disease is a worldwide and increasingly prevalent health problem. Many researchers have identified complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases. These affect immune response and influence the progression of disease. However, the diversity of bacterial changes in such cases make it difficult to identify a specific microorganism to target for adjustment. Recent research evidence suggests that common bacterial variations present in allergic respiratory disease are associated with immune disorders. This finding could lead to the discovery of potential therapeutic targets in cases of allergic respiratory disease. In this review, we summarize current knowledge of bacteria changes in cases of allergic respiratory disease, to identify changes commonly associated with immune disorders, and thus provide a theoretical basis for targeting therapies of allergic respiratory disease through effective modulation of key bacteria.
过敏性呼吸道疾病是一个全球性且日益普遍的健康问题。许多研究人员已经确定，过敏性呼吸道疾病患者的呼吸道和肠道微生物群存在复杂变化。这些变化会影响免疫反应并影响疾病的进展。然而，此类病例中细菌变化的多样性使得难以确定一种特定的微生物作为调整靶点。最近的研究证据表明，过敏性呼吸道疾病中常见的细菌变异与免疫紊乱有关。这一发现可能会促成在过敏性呼吸道疾病病例中发现潜在的治疗靶点。在本综述中，我们总结了目前关于过敏性呼吸道疾病病例中细菌变化的知识，以确定通常与免疫紊乱相关的变化，从而为通过有效调节关键细菌来靶向治疗过敏性呼吸道疾病提供理论依据。
