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柳属嫩枝中的水杨苷抑制 3T3-L1 细胞成脂分化

Anti-Adipogenic Effects of Salicortin from the Twigs of Weeping Willow () in 3T3-L1 Cells.

机构信息

Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.

Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Korea.

出版信息

Molecules. 2022 Oct 17;27(20):6954. doi: 10.3390/molecules27206954.

DOI:10.3390/molecules27206954
PMID:36296558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9609119/
Abstract

(), the "weeping willow," has been used in traditional Korean medicine to treat pain and fever due to its high concentrations of salicylic acid and salicin. The present study investigated bioactive compounds from twigs to discover bioactive natural products. Phytochemical investigation of the ethanol (EtOH) extract of twigs followed by liquid chromatography-mass spectrometry (LC/MS)-based analysis led to the isolation of two salicin derivatives, salicortinol and salicortin, the structures of which were determined by interpretation of their NMR spectra and data from the LC/MS analysis. To the best of our knowledge, this is the first report of salicortinol isolated from . The isolated compounds were evaluated for their anti-adipogenic effects in 3T3-L1 cells. Both salicortinol and salicortin were found to significantly inhibit adipocyte differentiation in 3T3-L1 cells. In particular, salicortin exhibited a strong inhibitory effect on lipid accumulation. Furthermore, salicortin inhibited the expression of lipogenic and adipogenic transcription factors, including FASN, FABP4, C/EBPα, C/EBPβ, and PPARγ, without inducing cytotoxicity. These results suggest that salicortin could be a potential therapeutic compound for the prevention or treatment of metabolic disorders such as obesity.

摘要

(), 即“垂柳”，因其高浓度的水杨酸和柳醇，在传统的韩国医学中被用于治疗疼痛和发热。本研究从 的嫩枝中发现生物活性化合物，以探索生物活性天然产物。对 嫩枝的乙醇（EtOH）提取物进行植物化学研究，并通过基于液相色谱-质谱（LC/MS）的分析，导致分离出两种柳醇衍生物，柳醇甙和柳醇甙，其结构通过其 NMR 谱和 LC/MS 分析数据的解释来确定。据我们所知，这是首次从 中分离出柳醇甙。对分离得到的化合物进行了在 3T3-L1 细胞中的抗脂肪生成作用评价。柳醇甙和柳醇甙都被发现能显著抑制 3T3-L1 细胞中的脂肪细胞分化。特别是，柳醇甙对脂质积累具有很强的抑制作用。此外，柳醇甙还抑制了脂肪生成和脂肪生成转录因子的表达，包括 FASN、FABP4、C/EBPα、C/EBPβ 和 PPARγ，而没有诱导细胞毒性。这些结果表明，柳醇甙可能是预防或治疗肥胖等代谢紊乱的潜在治疗化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/3e87cd23ba2f/molecules-27-06954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/089fbd7fd370/molecules-27-06954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/2a979e1fb5de/molecules-27-06954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/7d8720b41b8d/molecules-27-06954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/5e60f8adfba4/molecules-27-06954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/3e87cd23ba2f/molecules-27-06954-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/089fbd7fd370/molecules-27-06954-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/2a979e1fb5de/molecules-27-06954-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/7d8720b41b8d/molecules-27-06954-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/5e60f8adfba4/molecules-27-06954-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b93/9609119/3e87cd23ba2f/molecules-27-06954-g005.jpg

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