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三萜类化合物抗病毒活性的最新进展

Recent Advances in Antiviral Activities of Triterpenoids.

作者信息

Liu Yue, Yang Liangyu, Wang Hong, Xiong Yongai

机构信息

Department of Pharmaceutics, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563000, China.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi 563000, China.

出版信息

Pharmaceuticals (Basel). 2022 Sep 21;15(10):1169. doi: 10.3390/ph15101169.

Abstract

Triterpenoids, important secondary plant metabolites made up of six isoprene units, are found widely in higher plants and are studied for their structural variety and wide range of bioactivities, including antiviral, antioxidant, anticancer, and anti-inflammatory properties. Numerous studies have demonstrated that different triterpenoids have the potential to behave as potential antiviral agents. The antiviral activities of triterpenoids and their derivatives are summarized in this review, with examples of oleanane, ursane, lupane, dammarane, lanostane, and cycloartane triterpenoids. We concentrated on the tetracyclic and pentacyclic triterpenoids in particular. Furthermore, the particular viral types and possible methods, such as anti-human immunodeficiency virus (HIV), anti-influenza virus, and anti-hepatitis virus, are presented in this article. This review gives an overview and a discussion of triterpenoids as potential antiviral agents.

摘要

三萜类化合物是由六个异戊二烯单元组成的重要次生植物代谢产物,广泛存在于高等植物中,因其结构多样性和广泛的生物活性而受到研究,这些生物活性包括抗病毒、抗氧化、抗癌和抗炎特性。大量研究表明,不同的三萜类化合物有可能作为潜在的抗病毒剂。本文综述了三萜类化合物及其衍生物的抗病毒活性,并列举了齐墩果烷型、乌苏烷型、羽扇豆烷型、达玛烷型、羊毛脂烷型和环阿尔廷烷型三萜类化合物的例子。我们特别关注四环和五环三萜类化合物。此外,本文还介绍了特定的病毒类型以及可能的方法,如抗人类免疫缺陷病毒(HIV)、抗流感病毒和抗肝炎病毒。这篇综述对三萜类化合物作为潜在抗病毒剂进行了概述和讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df6a/9607549/8920a8cc57b5/pharmaceuticals-15-01169-g001.jpg

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