de Carvalho Lima Elidamar Nunes, Barros Martins Guilherme Leão, Diaz Ricardo Sobhie, Schechter Mauro, Piqueira José Roberto Castilho, Justo João Francisco
Telecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, Avenida Prof. Luciano Gualberto, Travessa 3, 158, São Paulo 05508-010, Brazil.
Infectious Diseases Division, Department of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil.
Pharmaceutics. 2022 Sep 22;14(10):2004. doi: 10.3390/pharmaceutics14102004.
Melanoma is an aggressive skin cancer that affects approximately 140,000 people worldwide each year, with a high fatality rate. Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as , have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new possibilities as antitumor agents. This systematic review aims to arouse interest and present the possibilities of using combined with carbon-based nanomaterials as an antineoplastic agent in the treatment and prevention of melanoma. Limitations and advances in melanoma treatment using functionalized carbon nanomaterials are discussed here. Moreover, this review provides the basis for further studies designed to fully explore the potential of carbon nanomaterials associated with in the treatment of various cancers, with a focus on melanoma.
黑色素瘤是一种侵袭性皮肤癌，每年全球约有14万人受其影响，死亡率很高。在更严重的病例中，现有的治疗方式疗效有限。因此，寻找包括免疫疗法在内的新的治疗方式来治愈、减轻和/或预防癌症非常重要且迫切需要。与某些植物材料相关的碳纳米颗粒，如，已显示出具有吸引力的抗肿瘤活性，主要源自芦荟素、芦荟大黄素、巴巴芦荟苷、乙酰甘露聚糖和八肽等化合物，因此作为抗肿瘤药物展现出了新的可能性。本系统综述旨在引起关注，并介绍与碳基纳米材料联合使用作为抗肿瘤药物治疗和预防黑色素瘤的可能性。本文讨论了使用功能化碳纳米材料治疗黑色素瘤的局限性和进展。此外，本综述为进一步研究提供了基础，这些研究旨在充分探索与相关的碳纳米材料在治疗各种癌症，尤其是黑色素瘤方面的潜力。
