Bao Qi, Zhang Ziheng, Yu Baocheng, Sun Huize, Leung Polly Hang-Mei, Tao Xiaoming
Research Institute for Intelligent Wearable Systems, The Hong Kong Polytechnic University, Hong Kong 999077, China.
School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong 999077, China.
Polymers (Basel). 2022 Oct 18;14(20):4399. doi: 10.3390/polym14204399.
Infectious microbial diseases are a major public health hazard, calling for more innovative antimicrobials. Herein, polylactic acid (PLA) oligomers have been explored and reported as a bio-safe and eco-friendly functional antimicrobial agent against pathogens, such as viruses (H1N1, H3N2, and SARS-CoV-2), bacteria (E. coli, S. aureus, K. pneumoniae, MRSA), and fungi (C. albicans). The PLA oligomers were prepared by direct catalyst-free condensation polymerization of l-lactic acid monomers and characterized by FT-IR and 1H-NMR. The antiviral results demonstrate that PLA oligomers possess robust (inhibiting rate > 99%) and rapid (<20 min) antiviral activity against two pandemic ssRNA viruses, including influenza A virus (IAV) and coronavirus (CoV). Furthermore, the PLA oligomers exhibit high antibacterial activities against both Gram negative (G−) and Gram positive (G+) bacteria. The PLA oligomers also perform efficiently in killing a large amount of C. albicans as high as 105 cfu/mL down to zero at the concentration of 10 mg/mL. Thus, the broad-spectrum antimicrobial activity endowed the PLA oligomers with a promising biocidal option, except antibiotics in a wide range of applications, such as medical textiles, food preservation, water disinfection, and personal hygiene, in light of their unique biodegradability and biocompatibility.
传染性微生物疾病是重大的公共卫生危害，因此需要更多创新型抗菌药物。在此，聚乳酸（PLA）低聚物已被研究并报道为一种对病原体具有生物安全性和生态友好性的功能性抗菌剂，这些病原体包括病毒（H1N1、H3N2和SARS-CoV-2）、细菌（大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌、耐甲氧西林金黄色葡萄球菌）和真菌（白色念珠菌）。PLA低聚物通过l-乳酸单体的直接无催化剂缩聚反应制备，并通过傅里叶变换红外光谱（FT-IR）和核磁共振氢谱（1H-NMR）进行表征。抗病毒结果表明，PLA低聚物对两种大流行的单链RNA病毒，包括甲型流感病毒（IAV）和冠状病毒（CoV），具有强大的（抑制率>99%）和快速的（<20分钟）抗病毒活性。此外，PLA低聚物对革兰氏阴性（G−）和革兰氏阳性（G+）细菌均表现出高抗菌活性。PLA低聚物在杀灭大量白色念珠菌方面也表现高效，在浓度为10 mg/mL时，可将高达105 cfu/mL的白色念珠菌杀灭至零。因此，鉴于其独特的生物降解性和生物相容性，广谱抗菌活性使PLA低聚物成为一种有前景的杀菌选择，可在医疗纺织品、食品保鲜、水消毒和个人卫生等广泛应用中替代抗生素。
