Opt Express. 2022 Aug 1;30(16):29665-29679. doi: 10.1364/OE.459805.
The detection of acetone in the gaseous form in exhaled breath using an integrated sensor can provide an effective tool for disease diagnostics as acetone is a marker for monitoring human metabolism. An on-chip acetone gas sensor based on the principle of Mach-Zehnder interferometer is proposed and demonstrated. The sensing arm of the device is activated with a composite film of polyethyleneimine and amido-graphene oxide as the gas-sensitive adsorption layer. The composite film demonstrates good selectivity to acetone gas, can be used repeatedly, and is stable in long-term use. Room temperature operation has been demonstrated for the sensor with high sensitivity under a 20 ppm acetone environment. The detection limit can reach 0.76 ppm, making it feasible to be used for the clinical diagnosis of diabetes and the prognosis of heart failure.
利用集成传感器检测呼出气体中的丙酮，为疾病诊断提供了一种有效的工具，因为丙酮是监测人体新陈代谢的标志物。本文提出并演示了一种基于马赫-曾德尔干涉仪原理的片上丙酮气体传感器。该器件的传感臂采用聚乙烯亚胺和酰胺化氧化石墨烯的复合薄膜作为气敏吸附层。该复合薄膜对丙酮气体具有良好的选择性，可重复使用，长期使用稳定。该传感器在 20 ppm 丙酮环境下具有高灵敏度，可在室温下工作。检测限可达到 0.76 ppm，可用于糖尿病的临床诊断和心力衰竭的预后。
