Gencer Aysegul, Atahan Ersan, Kadioglu Pinar, Mutlu Birsen
Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul, Turkey.
Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Endocrinology - Diabetes and Metabolism Diseases, Istanbul, Turkey.
ERJ Open Res. 2022 Oct 24;8(4). doi: 10.1183/23120541.00186-2022. eCollection 2022 Oct.
The aim of this study is to determine the frequency of obstructive sleep apnoea syndrome (OSAS) in a study group with the diagnosis of subclinical hypothyroidism and in a control group without the diagnosis of subclinical hypothyroidism. This study compares these two groups in terms of demographic characteristics, chronic diseases and especially polysomnographic data.
A total of 120 patients were included in this study. They consisted of 60 patients with newly diagnosed subclinical hypothyroidism and a control group of 60 patients with normal thyroid functions. Demographic, anthropometric, polysomnography data and Epworth Sleepiness Scale scores of the patients were recorded and compared.
Any significant difference in the frequency and severity of OSAS was not detected. A significant difference was found in the oxygen desaturation index (ODI), the apnoea-hypopnoea index (AHI) in rapid eye movement sleep, the AHI in supine sleep position and the arousal index of the group experiencing subclinical hypothyroidism with OSAS.
This study showed that there was no increase in OSAS frequency in patients with subclinical hypothyroidism, but it demonstrated that the ODI and the arousal index were significantly increased in OSAS patients diagnosed with subclinical hypothyroidism. It is thought that the diagnosis and treatment of OSAS in these patients may be important in preventing cardiovascular complications.
本研究的目的是确定诊断为亚临床甲状腺功能减退症的研究组以及未诊断为亚临床甲状腺功能减退症的对照组中阻塞性睡眠呼吸暂停综合征(OSAS)的发生率。本研究在人口统计学特征、慢性疾病尤其是多导睡眠图数据方面对这两组进行比较。
本研究共纳入120例患者。其中包括60例新诊断的亚临床甲状腺功能减退症患者和60例甲状腺功能正常的对照组患者。记录并比较患者的人口统计学、人体测量学、多导睡眠图数据及爱泼华嗜睡量表评分。
未检测到OSAS发生率和严重程度的任何显著差异。在亚临床甲状腺功能减退症合并OSAS组的氧饱和度下降指数(ODI)、快速眼动睡眠期呼吸暂停低通气指数(AHI)、仰卧睡眠位AHI及觉醒指数方面发现了显著差异。
本研究表明,亚临床甲状腺功能减退症患者的OSAS发生率没有增加,但表明在诊断为亚临床甲状腺功能减退症的OSAS患者中,ODI和觉醒指数显著升高。认为对这些患者的OSAS进行诊断和治疗对于预防心血管并发症可能很重要。