Fucà Elisa, Costanzo Floriana, Galassi Paolo, Celestini Laura, Villani Alberto, Valentini Diletta, Vicari Stefano
Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pediatric Unit, Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Front Psychol. 2024 Feb 6;14:1294908. doi: 10.3389/fpsyg.2023.1294908. eCollection 2023.
Subclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features associated with SH in children with DS.
The first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.
We included in this retrospective study 98 participants with DS aged 3-18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.
Participants with co-occurring SH exhibited significantly higher scores at several scales of the Conners' Parent Rating Scales Long Version - Revised. However, they did not exhibit more sleep problems than control group.
These results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS.
亚临床甲状腺功能减退症（SH）在唐氏综合征（DS）患者中尤为常见。尽管有大量证据表明SH与普通人群的精神病理症状和睡眠问题有关，但对于DS患儿中与SH相关的情绪和行为特征却知之甚少。
本研究的首要目的是调查一组同时患有SH的DS患儿与一组年龄和体重指数匹配但未同时患有SH的DS患儿在情绪和行为特征上的差异。本研究的第二个目的是调查这些组之间睡眠障碍的差异。
我们将98名3至18岁的DS参与者纳入这项回顾性研究，旨在探讨患有或未患有SH的DS患儿在情绪/行为问题以及睡眠困难方面的差异。
同时患有SH的参与者在康纳斯父母评定量表长版修订版的几个量表上得分显著更高。然而，他们并没有比对照组表现出更多的睡眠问题。
这些结果为疑似或确诊为SH的DS患儿的心理和神经精神评估提供了具体指征，突出了多学科方法在DS儿童和青少年临床护理中的重要性。
