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一位骑三轮车的骑行者：因变时性功能不全导致运动不耐受。

A Cyclist on a Tricyclic: Exercise Intolerance Due to Chronotropic Incompetence.

作者信息

Tanayan Christopher, Reddy Satyajit, Shah Ankit B, Wasfy Meagan M

机构信息

Cardiovascular Performance Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Department of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona, USA.

出版信息

JACC Case Rep. 2022 Oct 19;4(20):1335-1340. doi: 10.1016/j.jaccas.2022.05.038.

DOI:10.1016/j.jaccas.2022.05.038
PMID:36299644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9588449/
Abstract

Depression in athletes is prevalent, and antidepressant treatment may have a cardiovascular impact. We present a case, documented by serial exercise testing, of exertional intolerance due to chronotropic incompetence associated with tricyclic antidepressant use. This case underscores the importance of understanding the mechanism of action and side effects of antidepressants. ().

摘要

运动员中的抑郁症很普遍，抗抑郁治疗可能会对心血管产生影响。我们报告一例因使用三环类抗抑郁药导致变时性功能不全引起运动不耐受的病例，该病例通过系列运动试验得以记录。该病例强调了了解抗抑郁药作用机制和副作用的重要性。（）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/b87d250ff5df/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/8718b154ce6f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/a1ec41c4ecc1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/cf7985f51c64/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/b87d250ff5df/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/8718b154ce6f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/a1ec41c4ecc1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/cf7985f51c64/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f1b/9588449/b87d250ff5df/gr3.jpg

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本文引用的文献

1
Temporal Reduction in Chronotropic Index Predicts Risk of Cardiovascular Death Among Healthy Middle-Aged Men: a 28-Year Follow-Up Study.心率变时性指数的时间性降低可预测健康中年男性心血管死亡风险：一项28年的随访研究。
J Am Heart Assoc. 2016 Nov 23;5(12):e004555. doi: 10.1161/JAHA.116.004555.
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Depression in athletes: prevalence and risk factors.运动员中的抑郁症：患病率及风险因素。
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Br J Psychiatry. 1972 Jun;120(559):673-7. doi: 10.1192/bjp.120.559.673.
5
Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells.三环类抗抑郁药地昔帕明对培养的大鼠胶质瘤C6细胞中β-肾上腺素能受体的影响。
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6
Beta adrenergic receptor function in depression and the effect of antidepressant drugs.抑郁症中的β肾上腺素能受体功能及抗抑郁药物的作用。
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7
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.抗抑郁药治疗后大鼠大脑皮质中β肾上腺素能受体的突触前调节
J Pharmacol Exp Ther. 1978 Nov;207(2):446-57.
8
In vitro modulation of CNS beta-receptor number by antidepressants and beta-agonists.抗抑郁药和β-激动剂对中枢神经系统β受体数量的体外调节作用。
Eur J Pharmacol. 1979 Nov 16;59(3-4):297-301. doi: 10.1016/0014-2999(79)90294-2.