U'Prichard D C, Enna S J
Eur J Pharmacol. 1979 Nov 16;59(3-4):297-301. doi: 10.1016/0014-2999(79)90294-2.
In vitro incubation of rat cerebral cortex slices with antidepressant drugs reduced beta-adrenergic receptor binding of 3H-dihydroalprenolol by 30%. The decrease was maximum after 60 min, and was reversible after 120 min. (-)-Isoproterenol incubation caused a rapid and reversible loss (60%) of beta-receptor binding. Both effects were due to a decrease in beta-receptor sites. In vitro beta-receptor subsensitivity due to desipramine and isoproterenol was non-additive. The observed reversible loss of beta-receptor sites may be an initial phase of the beta-receptor down-regulation by antidepressants seen in vivo.
用抗抑郁药物对大鼠大脑皮质切片进行体外孵育，可使3H - 二氢阿普洛尔的β - 肾上腺素能受体结合减少30%。60分钟后减少量最大，120分钟后可逆转。（-）-异丙肾上腺素孵育导致β受体结合迅速且可逆地丧失（60%）。这两种效应均归因于β受体位点的减少。地昔帕明和异丙肾上腺素引起的体外β受体亚敏感性无相加作用。观察到的β受体位点的可逆丧失可能是体内所见抗抑郁药导致β受体下调的初始阶段。
