Departments of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, China.
Departments of Comprehensive Ultrasonography, The First Hospital of Jilin University, Changchun, Jilin, China.
Genet Res (Camb). 2022 Oct 14;2022:9304264. doi: 10.1155/2022/9304264. eCollection 2022.
Our study aimed to investigate the relationship between extracellular matrix 1 ( gene polymorphism and progression of liver fibrosis in the Chinese population.
A total 656 patients with hepatitis B virus (HBV) infection and 298 healthy individuals of the Chinese Han population were recruited for a retrospective case-control study. Of the disease group, 104 cases had chronic hepatitis B (CHB), 266 had LC, and 286 had hepatocellular carcinoma (HCC). Subjects were frequency-matched according to age and gender. Polymorphisms of the gene were examined using the MassARRAY SNP genotyping method.
There were no associations between genotype and allele frequencies of rs3737240 and rs13294 loci with the risk of CHB and CHB-related HCC. After adjustment for age, sex, smoking status, and drinking habits, the GT genotype was dramatically related to a reduced risk of chronic HBV infection in both non-HCC (OR = 0.68, 95% CI: 0.49-0.94) and total chronic HBV infection patients (OR = 0.75, 95% CI: 0.56-1.00). Haplotype analyses revealed twelve protective haplotypes against total chronic HBV infection and four against non-HCC chronic HBV infection.
gene polymorphism in rs3834087 and rs3754217 loci is associated with a reduced risk of chronic HBV infection but not with liver fibrosis development and the occurrence of HCC.
本研究旨在探讨细胞外基质 1（ 基因多态性与中国人群肝纤维化进展的关系。
采用回顾性病例对照研究，共纳入 656 例乙型肝炎病毒（HBV）感染患者和 298 例汉族健康对照者。其中，慢性乙型肝炎（CHB）104 例，代偿期肝硬化（LC）266 例，肝细胞癌（HCC）286 例。病例组和对照组按年龄和性别频率匹配。采用 MassARRAY SNP 基因分型法检测 基因多态性。
rs3737240 和 rs13294 位点的基因型和等位基因频率与 CHB 和 CHB 相关 HCC 的发病风险无关。校正年龄、性别、吸烟和饮酒习惯后，GT 基因型与非 HCC（OR=0.68，95%CI：0.49-0.94）和总慢性 HBV 感染患者（OR=0.75，95%CI：0.56-1.00）的慢性 HBV 感染风险显著降低相关。单倍型分析显示，12 种单倍型与总慢性 HBV 感染相关，4 种与非 HCC 慢性 HBV 感染相关。
rs3834087 和 rs3754217 位点的 基因多态性与慢性 HBV 感染的风险降低相关，但与肝纤维化的发展和 HCC 的发生无关。
