Yang Xin-Ying, Han Tong-Li, Lv Jun-Lan
Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Front Pediatr. 2022 Oct 10;10:1001775. doi: 10.3389/fped.2022.1001775. eCollection 2022.
We initially described two children who developed Guillain-Barré syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS "meets" RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely identification and intervention to remedy potentially fatal complications such as electrolyte disorder multisystem complications and kidney injury are crucial. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.
我们最初描述了两名患格林-巴利综合征（GBS）并并发横纹肌溶解症（RML）的儿童，并复习了文献中报道的5例成年患者。通过分析这7例患者的临床特征、实验室检查、治疗及预后数据，我们发现当GBS“遇上”RML时，最突出的特点如下：男性居多；肢体无力、疼痛及呼吸衰竭可由多种因素引起；肢体无力及呼吸肌麻痹比单纯GBS更严重；机械通气概率增加。神经电生理研究显示存在轴索性损害。密切监测并及时识别和干预以纠正潜在致命并发症如电解质紊乱、多系统并发症及肾损伤至关重要。通过血浆置换、腹膜透析及支持治疗，大多数患者的远期预后良好。
