Zhang Xiaofeng, Huang Pengpeng, Jin Zhenhua, Wu Yanfei
Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
PLoS One. 2025 Aug 1;20(8):e0328489. doi: 10.1371/journal.pone.0328489. eCollection 2025.
This study investigates the association between dietary anthocyanidins consumption and the risk of frailty in the general adult population using data from the National Health and Nutrition Examination Survey (NHANES).
A cross-sectional analysis of NHANES data was conducted, examining the relationship between dietary anthocyanidins intake and frailty risk. Dose-response relationships and subgroup analyses were performed to provide a comprehensive understanding of the associations.
The results indicate a significant inverse relationship between the consumption of specific anthocyanidin types, including malvidin and delphinidin, as well as total anthocyanidins, and the odds of frailty. Particularly, individuals aged 41-60 years and males exhibited a notable protective effect of anthocyanidins against frailty. Dose-response analyses revealed a U-shaped relationship between total anthocyanidins intake and frailty risk, with an optimal consumption level of 33.322 mg per day.
This pioneering study emphasizes the potential protective role of dietary anthocyanidins in mitigating frailty, especially among middle-aged individuals and males.
本研究利用美国国家健康与营养检查调查（NHANES）的数据，调查普通成年人群中膳食花青素摄入量与衰弱风险之间的关联。
对NHANES数据进行横断面分析，研究膳食花青素摄入量与衰弱风险之间的关系。进行剂量反应关系和亚组分析，以全面了解这些关联。
结果表明，包括锦葵色素和飞燕草色素在内的特定花青素类型以及总花青素的摄入量与衰弱几率之间存在显著的负相关关系。特别是，41 - 60岁的个体和男性中，花青素对衰弱具有显著的保护作用。剂量反应分析显示，总花青素摄入量与衰弱风险之间呈U形关系，最佳摄入量为每天33.322毫克。
这项开创性研究强调了膳食花青素在减轻衰弱方面的潜在保护作用，尤其是在中年个体和男性中。
