Fatima Nisar, Anwar Fareeha, Saleem Uzma, Khan Aslam, Ahmad Bashir, Shahzadi Irum, Ahmad Hammad, Ismail Tariq
Faculty of Pharmacy, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Pakistan.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
Front Nutr. 2022 Oct 11;9:1005341. doi: 10.3389/fnut.2022.1005341. eCollection 2022.
, a genus of the Solanaceae family, has historically been utilized in many different parts of the world as an anti-inflammatory for treating skin infections, wounds, and bodily aches and pains. The current study aimed to investigate the potential benefits of a methanolic extract of in the management of diabetes and underlying complications in alloxanized-induced diabetic rats.
Animals were divided into nine groups ( = 6). Four groups received different standard oral hypoglycemic agents; three groups received 100, 200, and 400 mg/kg of leaf extract for six consecutive weeks, and the remaining two were normal and disease control groups. All groups received alloxan (150 mg/kg) except for the normal control. Only those animals whose glucose levels were raised to 200 mg/dl were selected for the study. After a 6-week dosage period, various biochemical parameters, as well as HbA1c, antioxidant profile, oral glucose tolerance test (OGTT), insulin sensitivity, histopathology, and insulin resistance, were measured and compared with the untreated diabetic group.
leaf extract at a dose of 400 mg/kg showed potent antidiabetic activity by reducing blood glucose levels ( < 0.001) after 6 weeks of treatment. OGTT data showed that exhibited significant ( < 0.001) glucose tolerance by significantly reducing blood glucose levels in just 2 h post-treatment. Other tests showed that plant extract significantly increased ( < 0.001) insulin sensitivity and decreased ( < 0.001) insulin resistance. The biochemical profile showed reduced triglyceride and cholesterol, while the antioxidant profile showed restoration of antioxidant enzymes in the pancreas, kidney, and liver tissues of treated rats.
The present study indicated that crude extracts of increase insulin sensitivity and reduce hyperlipidemia in diabetic rats, which rationalizes the traditional medicinal use of this plant as an antidiabetic agent.
茄科的 属植物，在历史上已在世界许多不同地区被用作抗炎药，用于治疗皮肤感染、伤口以及身体的疼痛和酸痛。当前研究旨在调查 甲醇提取物在管理四氧嘧啶诱导的糖尿病大鼠的糖尿病及潜在并发症方面的潜在益处。
将动物分为九组（每组 = 6）。四组接受不同的标准口服降糖药；三组连续六周接受100、200和400毫克/千克的 叶提取物，其余两组为正常对照组和疾病对照组。除正常对照组外，所有组均接受四氧嘧啶（150毫克/千克）。仅选择那些血糖水平升高至200毫克/分升的动物进行研究。在为期6周的给药期后，测量各种生化参数以及糖化血红蛋白（HbA1c）、抗氧化谱、口服葡萄糖耐量试验（OGTT）、胰岛素敏感性、组织病理学和胰岛素抵抗，并与未治疗的糖尿病组进行比较。
在治疗6周后，400毫克/千克剂量的 叶提取物通过降低血糖水平显示出强效抗糖尿病活性（<0.001）。OGTT数据显示， 仅在治疗后2小时就通过显著降低血糖水平表现出显著的（<0.001）葡萄糖耐量。其他测试表明，植物提取物显著增加（<0.001）胰岛素敏感性并降低（<0.001）胰岛素抵抗。生化谱显示甘油三酯和胆固醇降低，而抗氧化谱显示治疗大鼠的胰腺、肾脏和肝脏组织中的抗氧化酶恢复。
本研究表明， 的粗提取物可增加糖尿病大鼠的胰岛素敏感性并降低高脂血症，这使该植物作为抗糖尿病药物的传统药用具有合理性。
