Hou Pengyi, Pi Yangyang, Jiao Ziming, Tian Xueyan, Hu Wenxuan, Zhang Yuhong, Zhao Yi, Wang Faxuan
School of Public Health and Management, Ningxia Medical University, Yinchuan, People's Republic of China.
Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Oct 25;15:3243-3254. doi: 10.2147/DMSO.S383098. eCollection 2022.
In recent decades, obesity has become an epidemic worldwide and is a risk factor for many chronic diseases. Lung function is also a predictor of various chronic diseases. However, research results on the association between obesity and lung function are inconsistent and few studies have evaluated the association between central obesity indicators and lung function. Therefore, this study explored the correlation between central obesity and lung function.
This study is a cross-sectional study. The basic participant characteristics were collected by questionnaire. A tape measure was used to measure waist circumference (WC) and hip circumference (HC). Body fat percentage was measured using an InBody370. Lung function parameters were measured using a digital spirometer connected to a computer (Chestgraph HI-101). R (R4.0.5) software was used for data analysis. A generalized linear model was used to analyze the association between obesity and lung function.
This study found that body mass index (BMI) adjusted for WC was negatively correlated with forced vital capacity (FVC) (β=-0.05 [-0.06, -0.03] in men, β=-0.05 [-0.07, -0.04] in women) and forced expiratory volume in 1 s (FEV1)(β=-0.02 [-0.03, -0.00] in men, β=-0.03 [-0.04, -0.02] in women). Body fat percentage was negatively correlated with FVC (β=-0.01 [-0.01, -0.01] in men, β=-0.01 [-0.01, -0.00] in women).
Central obesity and combined central and general obesity were more strongly positively correlated with lung function. WC-adjusted BMI was negatively correlated with lung function. Body fat percentage was negatively correlated with lung function.
近几十年来，肥胖已成为全球流行的疾病，并且是许多慢性疾病的危险因素。肺功能也是多种慢性疾病的预测指标。然而，关于肥胖与肺功能之间关联的研究结果并不一致，且很少有研究评估中心性肥胖指标与肺功能之间的关联。因此，本研究探讨了中心性肥胖与肺功能之间的相关性。
本研究为横断面研究。通过问卷调查收集参与者的基本特征。使用卷尺测量腰围（WC）和臀围（HC）。使用InBody370测量体脂百分比。使用连接到计算机的数字肺活量计（Chestgraph HI-101）测量肺功能参数。使用R（R4.0.5）软件进行数据分析。采用广义线性模型分析肥胖与肺功能之间的关联。
本研究发现，经WC校正的体重指数（BMI）与用力肺活量（FVC）呈负相关（男性β=-0.05[-0.06，-0.03]，女性β=-0.05[-0.07，-0.04]）以及与1秒用力呼气量（FEV1）呈负相关（男性β=-0.02[-0.03，-0.00]，女性β=-0.03[-0.04，-0.02]）。体脂百分比与FVC呈负相关（男性β=-0.01[-0.01，-0.01]，女性β=-0.01[-0.01，-0.00]）。
中心性肥胖以及中心性和全身性肥胖合并与肺功能呈更强的正相关。经WC校正的BMI与肺功能呈负相关。体脂百分比与肺功能呈负相关。
