Kim Mi-Hyun, Yun Kyung Eun, Kim Jimin, Park Eunkyo, Chang Yoosoo, Ryu Seungho, Kim Hyung-Lae, Kim Han-Na
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
Sci Rep. 2020 Nov 10;10(1):19417. doi: 10.1038/s41598-020-76474-8.
Although obesity is associated with numerous diseases, the risks of disease may depend on metabolic health. Associations between the gut microbiota, obesity, and metabolic syndrome have been reported, but differences in microbiomes according to metabolic health in the obese population have not been explored in previous studies. Here, we investigated the composition of gut microbiota according to metabolic health status in obese and overweight subjects. A total of 747 overweight or obese adults were categorized by metabolic health status, and their fecal microbiota were profiled using 16S ribosomal RNA gene sequencing. We classified these adults into a metabolically healthy group (MH, N = 317) without any components of metabolic syndrome or a metabolically unhealthy group (MU, N = 430) defined as having at least one metabolic abnormality. The phylogenetic and non-phylogenetic alpha diversity for gut microbiota were lower in the MU group than the MH group, and there were significant differences in gut microbiota bacterial composition between the two groups. We found that the genus Oscillospira and the family Coriobacteriaceae were associated with good metabolic health in the overweight and obese populations. This is the first report to describe gut microbial diversity and composition in metabolically healthy and unhealthy overweight and obese individuals. Modulation of the gut microbiome may help prevent metabolic abnormalities in the obese population.
尽管肥胖与多种疾病相关，但疾病风险可能取决于代谢健康状况。肠道微生物群、肥胖与代谢综合征之间的关联已有报道，但以往研究尚未探讨肥胖人群中根据代谢健康状况划分的微生物组差异。在此，我们根据肥胖和超重受试者的代谢健康状况调查了肠道微生物群的组成。共有747名超重或肥胖成年人根据代谢健康状况进行分类，并使用16S核糖体RNA基因测序对其粪便微生物群进行分析。我们将这些成年人分为无任何代谢综合征成分的代谢健康组（MH，N = 317）和定义为至少有一项代谢异常的代谢不健康组（MU，N = 430）。MU组肠道微生物群的系统发育和非系统发育α多样性低于MH组，两组之间肠道微生物群细菌组成存在显著差异。我们发现，颤螺菌属和放线菌科与超重和肥胖人群的良好代谢健康相关。这是第一份描述代谢健康和不健康的超重及肥胖个体肠道微生物多样性和组成的报告。调节肠道微生物群可能有助于预防肥胖人群的代谢异常。
