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多壳层扩散磁共振成像得出的自由水反映了阿尔茨海默病中的tau蛋白/神经炎症病理。

Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease.

作者信息

Nakaya Moto, Sato Noriko, Matsuda Hiroshi, Maikusa Norihide, Shigemoto Yoko, Sone Daichi, Yamao Tensho, Ogawa Masayo, Kimura Yukio, Chiba Emiko, Ohnishi Masahiro, Kato Koichi, Okita Kyoji, Tsukamoto Tadashi, Yokoi Yuma, Sakata Masuhiro, Abe Osamu

机构信息

Department of Radiology National Center Hospital of Neurology and Psychiatry Ogawa-Higashi Kodaira Tokyo Japan.

Department of Radiology Graduate School of Medicine University of Tokyo Hongo Bunkyo-ku Tokyo Japan.

出版信息

Alzheimers Dement (N Y). 2022 Oct 25;8(1):e12356. doi: 10.1002/trc2.12356. eCollection 2022.

DOI:10.1002/trc2.12356
PMID:36304723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9594557/
Abstract

INTRODUCTION

Free-water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET).

METHODS

Seventy-one participants underwent multi-shell diffusion MRI, F-THK5351 PET, C-Pittsburgh compound B PET, and neuropsychological assessments. They were categorized into two groups: healthy controls (HCs) ( = 40) and AD-spectrum group (AD-S) ( = 31) using the Centiloid scale with amyloid PET and cognitive function. We analyzed group comparisons in FW and PET, correlations between FW and PET, and correlation analysis with neuropsychological scores.

RESULTS

In AD-S group, there was a significant positive correlation between FW and F-THK5351 in the temporal lobes. In addition, there were negative correlations between FW and cognitive function in the temporal lobe and cingulate gyrus, and negative correlations between F-THK5351 and cognitive function in the same regions.

DISCUSSION

FW imaging could be a biomarker for tau in AD alongside clinical correlations.

摘要

引言

自由水（FW）成像作为扩散磁共振成像（MRI）的一种新分析方法，可显示神经炎症和神经变性。我们使用tau蛋白/炎症和淀粉样蛋白正电子发射断层扫描（PET）评估了阿尔茨海默病（AD）中的自由水情况。

方法

71名参与者接受了多壳层扩散MRI、F-THK5351 PET、C-匹兹堡化合物B PET以及神经心理学评估。使用基于淀粉样蛋白PET和认知功能的百分位数量表，将他们分为两组：健康对照组（HCs）（n = 40）和AD谱组（AD-S）（n = 31）。我们分析了FW与PET的组间比较、FW与PET之间的相关性以及与神经心理学评分的相关性分析。

结果

在AD-S组中，颞叶的FW与F-THK5351之间存在显著正相关。此外，颞叶和扣带回的FW与认知功能之间存在负相关，并且相同区域的F-THK5351与认知功能之间也存在负相关。

讨论

除了临床相关性外，FW成像可能是AD中tau蛋白的一种生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/6b21993f2bfd/TRC2-8-e12356-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/d98246279394/TRC2-8-e12356-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/6ee309f8440a/TRC2-8-e12356-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/6b21993f2bfd/TRC2-8-e12356-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/d98246279394/TRC2-8-e12356-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/6ee309f8440a/TRC2-8-e12356-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a29/9594557/6b21993f2bfd/TRC2-8-e12356-g003.jpg

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