Sone Daichi, Shigemoto Yoko, Ogawa Masayo, Maikusa Norihide, Okita Kyoji, Takano Harumasa, Kato Koichi, Sato Noriko, Matsuda Hiroshi
Integrative Brain Imaging Center National Center of Neurology and Psychiatry Tokyo Japan.
Department of Clinical and Experimental Epilepsy UCL Institute of Neurology London UK.
Alzheimers Dement (Amst). 2020 Nov 11;12(1):e12125. doi: 10.1002/dad2.12125. eCollection 2020.
The molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in Alzheimer's disease (AD) research.
We recruited 27 amyloid-positive individuals identified through C-Pittsburgh compound B (PiB) positron emission tomography (PET) and 31 amyloid-negative individuals with normal cognition. All participants underwent C-PiB and F-THK5351 PET and magnetic resonance imaging (MRI) with neurite orientation dispersion and density imaging (NODDI) protocol. The neurite density index (NDI), orientation dispersion index (ODI), and PET images were analyzed to calculate voxel-wise correlations among the imaging modalities and correlations with cognitions.
In the amyloid-positive participants, there were significant negative correlations between F-THK5351 and NDI and between F-THK5351 and ODI. The bilateral mesial and lateral temporal lobes were mainly involved. Regarding cognition, F-THK5351 showed more marked associations with all cognitive domains than the other modalities.
Tau and neuroinflammation in AD may reduce the neurite density and orientation dispersion, particularly in the mesial and lateral temporal lobes.
神经退行性变的分子机制，包括tau蛋白和神经突复杂性，是阿尔茨海默病（AD）研究中的一个重要课题。
我们招募了27名通过C-匹兹堡化合物B（PiB）正电子发射断层扫描（PET）鉴定为淀粉样蛋白阳性的个体和31名认知正常的淀粉样蛋白阴性个体。所有参与者均接受了C-PiB和F-THK5351 PET以及采用神经突方向离散度和密度成像（NODDI）方案的磁共振成像（MRI）检查。对神经突密度指数（NDI）、方向离散度指数（ODI）和PET图像进行分析，以计算各成像模态之间的体素相关性以及与认知的相关性。
在淀粉样蛋白阳性参与者中，F-THK5351与NDI之间以及F-THK5351与ODI之间存在显著负相关。主要涉及双侧内侧和外侧颞叶。关于认知，与其他模态相比，F-THK5351与所有认知领域的关联更为显著。
AD中的tau蛋白和神经炎症可能会降低神经突密度和方向离散度，尤其是在内侧和外侧颞叶。
