大剂量地西泮治疗新生儿破伤风。
Neonatal tetanus treated with high dosage diazepam.
作者信息
Khoo B H, Lee E L, Lam K L
出版信息
Arch Dis Child. 1978 Sep;53(9):737-9. doi: 10.1136/adc.53.9.737.
Abstract
The combination of continuous intravenous infusion of diazepam (20--40 mg/kg per day) and intragastric phenobarbitone (10--15 mg/kg per day in 4 divided doses) was used to treat 19 cases of neonatal tetanus. Mortality was 2/19 (11%). This regimen was considered to have reduced the mortality and the need for artificial ventilation. The main side effects encountered were severe drowsiness, coma, and apnoeic episodes which were reversible when the level of diazepam was reduced.
摘要
采用持续静脉输注地西泮（每日20 - 40毫克/千克）和胃内给予苯巴比妥（每日10 - 15毫克/千克，分4次给药）联合治疗19例新生儿破伤风。死亡率为2/19（11%）。该治疗方案被认为降低了死亡率及人工通气的需求。主要出现的副作用为严重嗜睡、昏迷和呼吸暂停发作，当地西泮剂量降低时这些副作用是可逆的。
相似文献
1
Neonatal tetanus treated with high dosage diazepam.大剂量地西泮治疗新生儿破伤风。
Arch Dis Child. 1978 Sep;53(9):737-9. doi: 10.1136/adc.53.9.737.
2
Failure of high dosage valium in the treatment of neonatal tetanus.高剂量安定治疗新生儿破伤风失败。
Paediatr Indones. 1980 Mar-Apr;20(3-4):51-6.
3
Neonatal tetanus: incidence and improved outcome with diazepam.新生儿破伤风：地西泮治疗的发病率及改善的预后
Dev Med Child Neurol. 1992 May;34(5):448-53. doi: 10.1111/j.1469-8749.1992.tb11458.x.
4
Neonatal tetanus treated with diazepam as single antispasmodic agent.以地西泮作为单一抗痉挛药物治疗新生儿破伤风。
Paediatr Indones. 1981 May-Jun;21(5-6):101-6.
5
Tetanus in childhood: report of a therapeutic trial of diazepam.儿童破伤风：地西泮治疗试验报告
Br Med J. 1966 Oct 8;2(5518):860-2. doi: 10.1136/bmj.2.5518.860.
6
Experiences in the management of tetanus neonatorum with particular reference to the role of diazepam.新生儿破伤风的管理经验，特别提及地西泮的作用。
East Afr Med J. 1974 Jan;51(1):33-43.
7
Neonatal tetanus. Evaluation of treatment and a proposal for classification of severity.新生儿破伤风。治疗评估及严重程度分类建议。
Paediatr Indones. 1976 Sep-Oct;16(9-10):345-54.
8
Tetanus in Haiti.海地的破伤风
Lancet. 1975 Feb 15;1(7903):383-6. doi: 10.1016/s0140-6736(75)91292-1.
9
High dosage diazepam as single antispasmodic agent in the treatment of neonatal tetanus.高剂量地西泮作为单一抗痉挛药物治疗新生儿破伤风。
Paediatr Indones. 1983 Sep-Oct;23(9-10):163-72.
10
Diazepam in tetanus.地西泮用于破伤风治疗。
Lancet. 1973 Aug 25;2(7826):454. doi: 10.1016/s0140-6736(73)92331-3.
引用本文的文献
1
Acute renal failure in tetanus: authors' reply.破伤风所致急性肾衰竭：作者回复
Indian J Pediatr. 2014 Nov;81(11):1275. doi: 10.1007/s12098-014-1365-z. Epub 2014 Feb 27.
2
Neonatal tetanus: a continuing challenge.新生儿破伤风：持续存在的挑战。
Indian J Pediatr. 2012 Dec;79(12):1648-50. doi: 10.1007/s12098-011-0666-8. Epub 2012 Jan 7.
3
Neonatal tetanus elimination in India-still a long way to go.印度消除新生儿破伤风——仍有很长的路要走。
Indian J Pediatr. 2011 Apr;78(4):491-2. doi: 10.1007/s12098-010-0302-z. Epub 2010 Dec 17.
4
Neonatal tetanus in Turkey; what has changed in the last decade?土耳其的新生儿破伤风；过去十年有哪些变化？
BMC Infect Dis. 2008 Aug 19;8:112. doi: 10.1186/1471-2334-8-112.
5
Tetanus.破伤风
J Neurol Neurosurg Psychiatry. 2000 Sep;69(3):292-301. doi: 10.1136/jnnp.69.3.292.
6
Neonatal tetanus: a continuing challenge in the southeast of Turkey: risk factors, clinical features and prognostic factors.新生儿破伤风：土耳其东南部面临的持续挑战：危险因素、临床特征及预后因素
Eur J Epidemiol. 1999 Feb;15(2):171-4. doi: 10.1023/a:1007500109522.
7
The evaluation of late sequelae of tetanus infection.
Indian J Pediatr. 1994 May-Jun;61(3):263-7. doi: 10.1007/BF02752221.
8
Neonatal tetanus--long-term residual handicaps.新生儿破伤风——长期残留残疾
Arch Dis Child. 1983 Jan;58(1):68-9. doi: 10.1136/adc.58.1.68.
本文引用的文献
1
Grading of tetanus to evaluate prognosis.破伤风分级以评估预后。
Indian J Med Sci. 1959 Oct;13:834-40.
2
Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class.安定（商标名）——一种新型苯二氮䓬类精神治疗药物的药理及临床研究
Curr Ther Res Clin Exp. 1961 Sep;3:405-25.
3
Experience with diazepam in tetanus.地西泮治疗破伤风的经验。
Br Med J. 1966 Oct 8;2(5518):862-5. doi: 10.1136/bmj.2.5518.862.
4
Tetanus in childhood: report of a therapeutic trial of diazepam.儿童破伤风：地西泮治疗试验报告
Br Med J. 1966 Oct 8;2(5518):860-2. doi: 10.1136/bmj.2.5518.860.
5
Fixed drug combinations and the displacement of bilirubin from albumin.固定剂量复方制剂与胆红素从白蛋白的置换
Pediatrics. 1971 Jul;48(1):139-41.
6
Intravenous diazepam in the treatment of prolonged seizure activity in neonates and infants.静脉注射地西泮治疗新生儿和婴儿的癫痫持续状态。
Dev Med Child Neurol. 1971 Oct;13(5):630-4. doi: 10.1111/j.1469-8749.1971.tb08328.x.
7
Experiences in the management of tetanus neonatorum with particular reference to the role of diazepam.新生儿破伤风的管理经验，特别提及地西泮的作用。
East Afr Med J. 1974 Jan;51(1):33-43.
8
Intensive therapy in neonatal tetanus.新生儿破伤风的强化治疗
Anaesthesia. 1974 May;29(3):356-62. doi: 10.1111/j.1365-2044.1974.tb00655.x.
9
The management of neonatal tetanus.新生儿破伤风的管理
Med J Malaysia. 1978 Mar;32(3):220-4.
Zotero 插件