大剂量地西泮治疗新生儿破伤风。
Neonatal tetanus treated with high dosage diazepam.
作者信息
Khoo B H, Lee E L, Lam K L
出版信息
Arch Dis Child. 1978 Sep;53(9):737-9. doi: 10.1136/adc.53.9.737.
Abstract
The combination of continuous intravenous infusion of diazepam (20--40 mg/kg per day) and intragastric phenobarbitone (10--15 mg/kg per day in 4 divided doses) was used to treat 19 cases of neonatal tetanus. Mortality was 2/19 (11%). This regimen was considered to have reduced the mortality and the need for artificial ventilation. The main side effects encountered were severe drowsiness, coma, and apnoeic episodes which were reversible when the level of diazepam was reduced.
摘要
采用持续静脉输注地西泮（每日20 - 40毫克/千克）和胃内给予苯巴比妥（每日10 - 15毫克/千克，分4次给药）联合治疗19例新生儿破伤风。死亡率为2/19（11%）。该治疗方案被认为降低了死亡率及人工通气的需求。主要出现的副作用为严重嗜睡、昏迷和呼吸暂停发作，当地西泮剂量降低时这些副作用是可逆的。
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