School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India.
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Chem Biol Interact. 2022 Dec 1;368:110238. doi: 10.1016/j.cbi.2022.110238. Epub 2022 Oct 25.
Polysaccharides (PS) represent a broad class of polymer-based compounds that have been extensively researched as therapeutics and excipients for drug delivery. As pharmaceutical carriers, PS have mostly found their use as adsorbents, suspending agents, as well as cross-linking agents for various formulations such as liposomes, nanoparticles, nanoemulsions, nano lipid carriers, microspheres etc. This is due to inherent properties of PS such as porosity, steric stability and swellability, insolubility in pH. There have been emerging reports on the use of PS as therapeutic agent due to its anti-inflammatory and anti-oxidative properties for various diseases. In particular, for Crohn's disease, ulcerative colitis and inflammatory bowel disease. However, determining the dosage, treatment duration and effective technology transfer of these therapeutic moieties have not occurred. This is due to the fact that PS are still at a nascent stage of development to a full proof therapy for a particular disease. Recently, a combination of polysaccharide which act as a prebiotic and a probiotic have been used as a combination to treat various intestinal and colorectal (CRC) related diseases. This has proven to be beneficial, has shown good in vivo correlation and is well reported. The present review entails a detailed description on the role of PS used as a therapeutic agent and as a formulation pertaining to gastrointestinal diseases.
多糖（PS）是一类广泛的聚合物化合物，已被广泛研究作为治疗剂和药物递送的赋形剂。作为药物载体，PS 主要用作吸附剂、悬浮剂以及各种制剂（如脂质体、纳米粒子、纳米乳液、纳米脂质载体、微球等）的交联剂。这是由于 PS 的固有性质，如多孔性、空间稳定性和溶胀性，在 pH 值下不溶解。由于 PS 具有抗炎和抗氧化特性，因此在各种疾病中作为治疗剂的应用已有报道。特别是在克罗恩病、溃疡性结肠炎和炎症性肠病中。然而，这些治疗成分的剂量、治疗持续时间和有效的技术转移尚未确定。这是因为 PS 仍处于发展的初期阶段，尚未成为特定疾病的全面有效治疗方法。最近，已将作为益生菌的多糖与作为益生元的多糖结合使用，用于治疗各种肠道和结直肠（CRC）相关疾病。这已被证明是有益的，已显示出良好的体内相关性，并得到了很好的报道。本综述详细描述了 PS 作为治疗剂和胃肠道疾病制剂的作用。
