Babu Achsha, Devi Rajeswari V, Ganesh V, Das Soumik, Dhanasekaran Sivaraman, Usha Rani G, Ramanathan Gnanasambandan
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.
Pandit Deendayal Energy University, Knowledge Corridor, Raisan Village, PDPU Road, Gandhinagar, Gujarat, 382426, India.
Reprod Sci. 2024 Jun;31(6):1508-1520. doi: 10.1007/s43032-023-01450-2. Epub 2024 Jan 16.
Polycystic ovary syndrome (PCOS) is a multifaceted disease with an intricate etiology affecting reproductive-aged women. Despite attempts to unravel the pathophysiology, the molecular mechanism of PCOS remains unknown. There are no effective or suitable therapeutic strategies available to ameliorate PCOS; however, the symptoms can be managed. In recent years, a strong association has been found between the gut microbiome and PCOS, leading to the formulation of novel ideas on the genesis and pathological processes of PCOS. Further, gut microbiome dysbiosis involving microbial metabolites may trigger PCOS symptoms via many mechanistic pathways including those associated with carbohydrates, short-chain fatty acids, lipopolysaccharides, bile acids, and gut-brain axis. We present the mechanistic pathways of PCOS-related microbial metabolites and therapeutic opportunities available to treat PCOS, such as prebiotics, probiotics, and fecal microbiota therapy. In addition, the current review highlights the emerging treatment strategies available to alleviate the symptoms of PCOS.
多囊卵巢综合征（PCOS）是一种病因复杂、影响育龄女性的多方面疾病。尽管人们试图阐明其病理生理学，但PCOS的分子机制仍然未知。目前尚无有效或合适的治疗策略来改善PCOS；然而，其症状可以得到控制。近年来，肠道微生物群与PCOS之间发现了紧密联系，这为PCOS的发病机制和病理过程带来了新的思路。此外，涉及微生物代谢产物的肠道微生物群失调可能通过多种机制途径引发PCOS症状，包括与碳水化合物、短链脂肪酸、脂多糖、胆汁酸和肠-脑轴相关的途径。我们介绍了与PCOS相关的微生物代谢产物的机制途径以及可用于治疗PCOS的治疗机会，如益生元、益生菌和粪便微生物群疗法。此外，本综述还强调了可用于缓解PCOS症状的新兴治疗策略。
