鞘内注射去甲肾上腺素对大鼠的屈肌反射具有剂量依赖性的抑制或促进作用。
Intrathecal noradrenaline has a dose-dependent inhibitory or facilitatory effect on the flexion reflex in the rat.
作者信息
Wiesenfeld-Hallin Z
出版信息
Acta Physiol Scand. 1987 Jul;130(3):507-11. doi: 10.1111/j.1748-1716.1987.tb08169.x.
The effect of intrathecal noradrenaline (NA) on the hamstring flexion reflex to subcutaneous electrical shocks was examined in unanaesthetized, decerebrate, spinalized rats. Low doses of NA (200 ng and 2 micrograms) depressed and high doses (20 micrograms and 200 micrograms) facilitated the reflex. It is suggested that the primary effect of NA in the dorsal horn is inhibitory and in the ventral horn excitatory. Furthermore, the neurons mediating these effects are more sensitive to NA in the dorsal horn than in the ventral horn.
在未麻醉、去大脑、脊髓横断的大鼠中，研究了鞘内注射去甲肾上腺素（NA）对皮下电击引起的腘绳肌屈曲反射的影响。低剂量的NA（200纳克和2微克）抑制该反射，高剂量（20微克和200微克）则增强该反射。提示NA在背角的主要作用是抑制性的，而在腹角是兴奋性的。此外，介导这些作用的神经元在背角比在腹角对NA更敏感。
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