拟尾孢菌素 A-C，三种新的聚酮衍生物来自内生真菌 TSS-1。
Pseudocercones A-C, three new polyketide derivatives from the endophytic fungus sp. TSS-1.
机构信息
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, P. R. China.
Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, P. R. China.
出版信息
Nat Prod Res. 2024 Apr;38(7):1248-1255. doi: 10.1080/14786419.2022.2138874. Epub 2022 Oct 29.
Chemical investigation of an EtOAc extract of the endophytic fungus sp. TSS-1 led to the isolation of three new polyketide derivatives, including one benzophenon derivative (), two spirocyclic polyketides ( and ), along with four known compounds (, , and ). Their structures and the absolute configurations were characterized by means of NMR, HRESIMS, C NMR and theoretical electronic circular dichroism calculations. Furthermore, all compounds were evaluated for their antibacterial activity against four microbial pathogens (, , and ), and compounds , , and displayed significant selective antibacterial activity against with MIC values ranging from 3.9 to 7.8 µg/mL.
从内生真菌 sp. TSS-1 的 EtOAc 提取物中进行化学研究，分离得到三个新的聚酮衍生物，包括一个二苯甲酮衍生物 ()、两个螺环聚酮 ( 和 )，以及四个已知化合物 (、、和 )。通过 NMR、HRESIMS、C NMR 和理论电子圆二色谱计算等方法确定了它们的结构和绝对构型。此外，还评估了所有化合物对四种微生物病原体（、、和 ）的抗菌活性，化合物 、 、 和 对 表现出显著的选择性抗菌活性，MIC 值范围为 3.9 至 7.8 μ g/mL。
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