Federal University of Pernambuco. Graduate program of Physical Therapy. Recife-PE, Brazil.
Clinical Epidemiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.
Asian Pac J Cancer Prev. 2022 Oct 1;23(10):3237-3245. doi: 10.31557/APJCP.2022.23.10.3237.
Handgrip strength (HGS) is an indicator of general muscular strength and in cancer patients acts as a relevant marker associated with mortality and health. This study aimed to evaluate the association between peripheral muscle function and health-related quality of life (HRQoL) in breast cancer (BC) survivors.
Systematic review registered on PROSPERO under number: CRD 42021225206. The searches were carried out on MEDLINE via Pubmed, PEDro, Cochrane Library, Embase, CINAHL via EBSCO and Science Direct databases. Observational studies evaluating the association between handgrip strength (HGS) and HRQoL in adult female BC survivors were included. No linguistic or time restrictions were applied. Two reviewers reviewed full texts for inclusion and performed data extraction and risk of bias using the Newcastle and Ottawa scale (NOS).
Five articles were included and involved 587 patients, mean age of 47 to 59 years. The percentage of decreased HGS ranged from 38.3% to 60.3%. HGS was associated with different quality of life measures. From meta-analysis including 220 patients, the correlation coefficient between HGS and HRQoL was 0.26 (95% CI: 0.07-0.35).
Breast cancer survivors face decline of HGS. In this population HGS was correlated with HRQoL. However, more evidence are necessary.
握力（HGS）是全身肌肉力量的指标，在癌症患者中是与死亡率和健康相关的重要标志物。本研究旨在评估乳腺癌（BC）幸存者外周肌肉功能与健康相关生活质量（HRQoL）之间的关系。
在 PROSPERO 上进行系统评价，注册号：CRD42021225206。通过 PubMed 检索 MEDLINE、PEDro、Cochrane 图书馆、Embase、EBSCO 中的 CINAHL 和 Science Direct 数据库。纳入评估成年女性 BC 幸存者握力（HGS）与 HRQoL 之间关系的观察性研究。未施加语言或时间限制。两位评审员对纳入的全文进行审查，并使用纽卡斯尔-渥太华量表（NOS）进行数据提取和偏倚风险评估。
纳入了 5 篇文章，共涉及 587 名患者，平均年龄为 47 至 59 岁。握力下降的百分比范围为 38.3%至 60.3%。HGS 与不同的生活质量指标相关。对包括 220 名患者的 Meta 分析显示，HGS 与 HRQoL 之间的相关系数为 0.26（95%CI：0.07-0.35）。
乳腺癌幸存者面临握力下降的问题。在该人群中，HGS 与 HRQoL 相关。然而，还需要更多的证据。
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