Francis G, Riley W
Am J Dis Child. 1987 Oct;141(10):1081-3. doi: 10.1001/archpedi.1987.04460100059025.
Three patients demonstrated transient neonatal hypothyroidism, presumably secondary to maternally derived thyrotropin (TSH)-blocking antibodies. Although transient, this disorder might not have been benign in the first child, who exhibited significant developmental delay. A thyroid scan was not helpful in making this diagnosis. Although uncommon, this disorder should be suspected in infants with a maternal history of autoimmune thyroid disease, multiple siblings with congenital hypothyroidism, or a clinical course characterized by continually suppressed TSH levels, despite low doses of levothyroxine sodium replacement. Measurement of TSH-blocking antibodies may be used in the diagnosis of transient neonatal hypothyroidism at birth and is becoming more readily available from reference laboratories. Once diagnosed, the patient may then be prepared for monitored withdrawal of levothyroxine replacement therapy at 2 to 3 years of age and will not be committed to lifelong replacement therapy.
三名患者出现短暂性新生儿甲状腺功能减退，推测继发于母体来源的促甲状腺激素（TSH）阻断抗体。尽管是短暂性的，但这种疾病在第一个孩子中可能并非良性，该患儿表现出明显的发育迟缓。甲状腺扫描对做出此诊断并无帮助。尽管这种疾病不常见，但对于有自身免疫性甲状腺疾病母亲病史、多个兄弟姐妹患有先天性甲状腺功能减退症的婴儿，或临床过程表现为尽管使用低剂量左甲状腺素钠替代治疗但TSH水平持续被抑制的婴儿，应怀疑患有此病。TSH阻断抗体的检测可用于出生时短暂性新生儿甲状腺功能减退症的诊断，并且越来越容易从参考实验室获得。一旦确诊，患者可在2至3岁时准备接受左甲状腺素替代治疗的监测撤药，而无需终身接受替代治疗。
