Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases.
作者信息
Rossi Sharyn L, Subramanian Preeti, Bu Guojun, Di Polo Adriana, Golde Todd E, Bovenkamp Diane E
机构信息
BrightFocus Foundation, 22512 Gateway Center Dr, 20871, Clarksburg, MD, USA.
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
出版信息
Mol Neurodegener. 2022 Oct 31;17(1):68. doi: 10.1186/s13024-022-00570-8.
Abstract
摘要
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本文引用的文献
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Sci Transl Med. 2021 Sep 29;13(613):eabc9375. doi: 10.1126/scitranslmed.abc9375.
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Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition.视网膜病变中的病理性血管生成涉及细胞衰老，并且可以通过 BCL-xL 抑制进行治疗性消除。
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is associated with longevity independent of Alzheimer's disease.与阿尔茨海默病无关，与长寿相关。
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Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy.中性粒细胞胞外诱捕网靶向衰老血管以实现视网膜病变中的组织重塑。
Science. 2020 Aug 21;369(6506). doi: 10.1126/science.aay5356.
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Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease.评估与阿尔茨海默病患者病理性 Tau 相关的脑储备和认知储备的人口统计学、遗传学和影像学变量。
JAMA Neurol. 2020 May 1;77(5):632-642. doi: 10.1001/jamaneurol.2019.5154.
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Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.载脂蛋白 E3 基督城纯合子对常染色体显性阿尔茨海默病的抗性：一例报告。
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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.清除衰老的神经胶质细胞可预防tau 依赖性病变和认知能力下降。
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