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基于跨层双线性池化的糖尿病视网膜病变分级算法研究

[Research on grading algorithm of diabetic retinopathy based on cross-layer bilinear pooling].

作者信息

Liang Liming, Peng Renjie, Feng Jun, Yin Jiang

机构信息

School of Electrical Engineering and Automation, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, P. R. China.

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Oct 25;39(5):928-936. doi: 10.7507/1001-5515.202104038.

DOI:10.7507/1001-5515.202104038
PMID:36310481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9927708/
Abstract

Considering the small differences between different types in the diabetic retinopathy (DR) grading task, a retinopathy grading algorithm based on cross-layer bilinear pooling is proposed. Firstly, the input image is cropped according to the Hough circle transform (HCT), and then the image contrast is improved by the preprocessing method; then the squeeze excitation group residual network (SEResNeXt) is used as the backbone of the model, and a cross-layer bilinear pooling module is introduced for classification. Finally, a random puzzle generator is introduced in the training process for progressive training, and the center loss (CL) and focal loss (FL) methods are used to further improve the effect of the final classification. The quadratic weighted Kappa (QWK) is 90.84% in the Indian Diabetic Retinopathy Image Dataset (IDRiD), and the area under the receiver operating characteristic curve (AUC) in the Messidor-2 dataset (Messidor-2) is 88.54%. Experiments show that the algorithm proposed in this paper has a certain application value in the field of diabetic retina grading.

摘要

考虑到糖尿病视网膜病变(DR)分级任务中不同类型之间的细微差异,提出了一种基于跨层双线性池化的视网膜病变分级算法。首先,根据霍夫圆变换(HCT)裁剪输入图像,然后通过预处理方法提高图像对比度;接着,将挤压激励组残差网络(SEResNeXt)用作模型的主干,并引入跨层双线性池化模块进行分类。最后,在训练过程中引入随机拼图生成器进行渐进式训练,并使用中心损失(CL)和焦点损失(FL)方法进一步提高最终分类的效果。在印度糖尿病视网膜病变图像数据集(IDRiD)中,二次加权卡帕(QWK)为90.84%,在梅西多-2数据集(Messidor-2)中,受试者工作特征曲线下面积(AUC)为88.54%。实验表明,本文提出的算法在糖尿病视网膜分级领域具有一定的应用价值。

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本文引用的文献

1
IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge.IDRiD:糖尿病视网膜病变 - 分割与分级挑战赛。
Med Image Anal. 2020 Jan;59:101561. doi: 10.1016/j.media.2019.101561. Epub 2019 Oct 3.
2
Reproduction study using public data of: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs.使用公共数据进行生殖研究:开发和验证一种用于眼底照片中糖尿病性视网膜病变检测的深度学习算法。
PLoS One. 2019 Jun 6;14(6):e0217541. doi: 10.1371/journal.pone.0217541. eCollection 2019.
3
Joint segmentation and classification of retinal arteries/veins from fundus images.眼底图像中视网膜动脉/静脉的联合分割与分类。
Artif Intell Med. 2019 Mar;94:96-109. doi: 10.1016/j.artmed.2019.02.004. Epub 2019 Feb 19.
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Multi-Cell Multi-Task Convolutional Neural Networks for Diabetic Retinopathy Grading.用于糖尿病视网膜病变分级的多细胞多任务卷积神经网络
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:2724-2727. doi: 10.1109/EMBC.2018.8512828.
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Non-Mydriatic Fundus Retinography in Screening for Diabetic Retinopathy: Agreement Between Family Physicians, General Ophthalmologists, and a Retinal Specialist.非散瞳眼底视网膜照相术在糖尿病视网膜病变筛查中的应用:家庭医生、普通眼科医生与视网膜专科医生之间的一致性
Front Endocrinol (Lausanne). 2018 May 18;9:251. doi: 10.3389/fendo.2018.00251. eCollection 2018.
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Diabetic macular edema grading in retinal images using vector quantization and semi-supervised learning.利用矢量量化和半监督学习对视网膜图像中的糖尿病性黄斑水肿进行分级
Technol Health Care. 2018;26(S1):389-397. doi: 10.3233/THC-174704.
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IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045.国际糖尿病联盟(IDF)糖尿病地图集:2017 年全球糖尿病患病率估计数和 2045 年预测值。
Diabetes Res Clin Pract. 2018 Apr;138:271-281. doi: 10.1016/j.diabres.2018.02.023. Epub 2018 Feb 26.
8
Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.深度学习算法在视网膜眼底照片糖尿病视网膜病变检测中的开发与验证。
JAMA. 2016 Dec 13;316(22):2402-2410. doi: 10.1001/jama.2016.17216.
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[International clinical diabetic retinopathy disease severity scale].
Nihon Rinsho. 2010 Nov;68 Suppl 9:228-35.
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Evaluation of a computer-aided diagnosis system for diabetic retinopathy screening on public data.基于公共数据集评估糖尿病视网膜病变筛查的计算机辅助诊断系统。
Invest Ophthalmol Vis Sci. 2011 Jul 1;52(7):4866-71. doi: 10.1167/iovs.10-6633.